Kulkarni Ravikumar S, Sarkar Amitabh, Goyal Sandeep
Department of Oral Pathology, Surendera Dental College and Research Institute, H. H. Gardens, Sri Ganganagar, Rajasthan 335001, India.
Case Rep Dent. 2013;2013:565721. doi: 10.1155/2013/565721. Epub 2013 May 21.
Ameloblastic fibroma (AF) is an uncommon mixed neoplasm of odontogenic origin frequently seen in the second decade of life. It mainly presents as an intrabony lesion but can even occur peripherally. Histologically, our case showed hypercellular areas, an uncommon feature seen in typical AF. Whether this benign lesion is treated by mode of enucleation and curettage or by extensive surgery is still a topic of debate. An extensive surgical treatment is suggested as the initial approach due to its high recurrence rate (18%) and the greater chances of recurrent AFs transforming into ameloblastic fibrosarcoma (45%), together with a long-term followup. We report a case of recurrent AF with hypercellular ectomesenchyme which developed a year after its conservative removal. We conclude that in recurrent AF sufficient sections of the pathological specimen are to be taken to rule out any malignant changes that might have begun in focal areas.
成釉细胞纤维瘤(AF)是一种罕见的牙源性混合性肿瘤,常见于生命的第二个十年。它主要表现为骨内病变,但也可发生于外周。组织学上,我们的病例显示有细胞增多区域,这在典型的AF中并不常见。这种良性病变究竟采用摘除刮治术还是广泛手术治疗仍是一个有争议的话题。鉴于其高复发率(18%)以及复发性AF转化为成釉细胞纤维肉瘤的可能性较大(45%),同时考虑到需要长期随访,建议将广泛手术治疗作为初始治疗方法。我们报告一例复发性AF病例,其细胞增多的外间充质在保守切除一年后出现。我们得出结论,对于复发性AF,应取足够的病理标本切片,以排除可能在局部区域开始的任何恶性变化。