腹腔镜手术与全身免疫反应。
Laparoscopic surgery and the systemic immune response.
作者信息
Vittimberga F J, Foley D P, Meyers W C, Callery M P
机构信息
Department of Surgery, University of Massachusetts Medical Center, Worcester 01655-0333, USA.
出版信息
Ann Surg. 1998 Mar;227(3):326-34. doi: 10.1097/00000658-199803000-00003.
OBJECTIVE
The authors review studies relating to the immune responses evoked by laparoscopic surgery.
SUMMARY BACKGROUND DATA
Laparoscopic surgery has gained rapid acceptance based on clinical grounds. Patients benefit from faster recovery, decreased pain, and quicker return to normal activities. Only more recently have attempts been made to identify the metabolic and immune responses that may underlie this clinical success. The immune responses to laparoscopy are now being evaluated in relation to the present knowledge of immune responses to traditional laparotomy and surgery in general.
METHODS
A review of the published literature of the immune and metabolic responses to laparoscopy was performed. Laparoscopic surgery is compared with the traditional laparotomy on the basis of local and systemic immune responses and patterns of tumor growth. The impact of pneumoperitoneum and insufflation gases on the immune response is also reviewed.
CONCLUSIONS
The systemic immune responses for surgery in general may not apply to laparoscopic surgery. The body's response to laparoscopy is one of lesser immune activation as opposed to immunosuppression.
目的
作者回顾与腹腔镜手术引发的免疫反应相关的研究。
总结背景数据
基于临床依据，腹腔镜手术已迅速得到认可。患者受益于更快的恢复、减轻的疼痛以及更快恢复正常活动。直到最近才有人尝试确定可能是这种临床成功基础的代谢和免疫反应。目前正在根据对传统剖腹手术及一般手术免疫反应的现有认识来评估对腹腔镜手术的免疫反应。
方法
对已发表的关于腹腔镜手术免疫和代谢反应的文献进行综述。基于局部和全身免疫反应以及肿瘤生长模式，将腹腔镜手术与传统剖腹手术进行比较。还综述了气腹和充气气体对免疫反应的影响。
结论
一般手术的全身免疫反应可能不适用于腹腔镜手术。身体对腹腔镜手术的反应是免疫激活程度较低，而非免疫抑制。
Zotero 插件