Kobayashi I, Imamura K, Yamada M, Okano M, Yara A, Ikema S, Ishikawa N
Department of Paediatrics, Hokkaido University School of Medicine, Sapporo, Japan.
Clin Exp Immunol. 1998 Mar;111(3):527-31. doi: 10.1046/j.1365-2249.1998.00523.x.
Autoimmune enteropathy (AIE) is a rare disorder characterized by intractable diarrhoea and antienterocyte autoantibody. In this study, we detected a 75-kD autoantigen which distributed through the whole intestine and the kidney, as assessed by Western blot analysis using sera from two unrelated cases of AIE associated with nephropathy. Our results suggest that the detection of the autoantibody against the 75-kD antigen has a diagnostic value in AIE and that the autoimmune reaction against the 75-kD antigen may be implicated in the development of intestinal and renal tissue damage in this rare disorder.
自身免疫性肠病（AIE）是一种罕见的疾病，其特征为顽固性腹泻和抗肠上皮细胞自身抗体。在本研究中，我们检测到一种75-kD自身抗原，通过使用来自两例与肾病相关的非相关AIE病例的血清进行蛋白质印迹分析评估，该抗原分布于整个肠道和肾脏。我们的结果表明，检测针对75-kD抗原的自身抗体在AIE中具有诊断价值，并且针对75-kD抗原的自身免疫反应可能与这种罕见疾病中肠道和肾脏组织损伤的发生有关。
