一种75-kD自身抗原，可被患有与肾病相关的X连锁自身免疫性肠病患者的血清识别。
A 75-kD autoantigen recognized by sera from patients with X-linked autoimmune enteropathy associated with nephropathy.
作者信息
Kobayashi I, Imamura K, Yamada M, Okano M, Yara A, Ikema S, Ishikawa N
机构信息
Department of Paediatrics, Hokkaido University School of Medicine, Sapporo, Japan.
出版信息
Clin Exp Immunol. 1998 Mar;111(3):527-31. doi: 10.1046/j.1365-2249.1998.00523.x.
Abstract
Autoimmune enteropathy (AIE) is a rare disorder characterized by intractable diarrhoea and antienterocyte autoantibody. In this study, we detected a 75-kD autoantigen which distributed through the whole intestine and the kidney, as assessed by Western blot analysis using sera from two unrelated cases of AIE associated with nephropathy. Our results suggest that the detection of the autoantibody against the 75-kD antigen has a diagnostic value in AIE and that the autoimmune reaction against the 75-kD antigen may be implicated in the development of intestinal and renal tissue damage in this rare disorder.
摘要
自身免疫性肠病（AIE）是一种罕见的疾病，其特征为顽固性腹泻和抗肠上皮细胞自身抗体。在本研究中，我们检测到一种75-kD自身抗原，通过使用来自两例与肾病相关的非相关AIE病例的血清进行蛋白质印迹分析评估，该抗原分布于整个肠道和肾脏。我们的结果表明，检测针对75-kD抗原的自身抗体在AIE中具有诊断价值，并且针对75-kD抗原的自身免疫反应可能与这种罕见疾病中肠道和肾脏组织损伤的发生有关。
相似文献
1
A 75-kD autoantigen recognized by sera from patients with X-linked autoimmune enteropathy associated with nephropathy.一种75-kD自身抗原，可被患有与肾病相关的X连锁自身免疫性肠病患者的血清识别。
Clin Exp Immunol. 1998 Mar;111(3):527-31. doi: 10.1046/j.1365-2249.1998.00523.x.
2
Identification of an autoimmune enteropathy-related 75-kilodalton antigen.一种自身免疫性肠病相关的75千道尔顿抗原的鉴定。
Gastroenterology. 1999 Oct;117(4):823-30. doi: 10.1016/s0016-5085(99)70340-9.
3
Clinical and molecular aspects of autoimmune enteropathy and immune dysregulation, polyendocrinopathy autoimmune enteropathy X-linked syndrome.自身免疫性肠病以及免疫失调、多内分泌腺病、自身免疫性肠病X连锁综合征的临床与分子学方面
Curr Opin Gastroenterol. 2008 Nov;24(6):742-8. doi: 10.1097/MOG.0b013e32830c9022.
4
A Japanese family of X-linked auto-immune enteropathy with haemolytic anaemia and polyendocrinopathy.
Eur J Pediatr. 1993 Apr;152(4):313-5. doi: 10.1007/BF01956741.
5
Autoimmune enteropathy and nephropathy with circulating anti-epithelial cell antibodies.伴有循环抗上皮细胞抗体的自身免疫性肠病和肾病
J Pediatr. 1991 Jun;118(6):858-64. doi: 10.1016/s0022-3476(05)82195-x.
6
Combination therapy with tacrolimus and betamethasone for a patient with X-linked auto-immune enteropathy.他克莫司与倍他米松联合治疗一名X连锁自身免疫性肠病患者。
Eur J Pediatr. 1995 Jul;154(7):594-5. doi: 10.1007/BF02074852.
7
[Autoimmune enteropathy in children].[儿童自身免疫性肠病]
Ned Tijdschr Geneeskd. 2011;155:A3246.
8
Autoimmune enteropathy and colitis: is there a generalised autoimmune gut disorder?自身免疫性肠病和结肠炎：是否存在一种全身性自身免疫性肠道疾病？
Gut. 1991 Jan;32(1):36-42. doi: 10.1136/gut.32.1.36.
9
A new antigen recognized by anti-liver-kidney-microsome antibody (LKMA).一种被抗肝肾微粒体抗体（LKMA）识别的新抗原。
Clin Exp Immunol. 1989 Mar;75(3):354-8.
10
Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy.早期发病自身免疫性肠炎严重型中 FOXP3 表达减少和调节性 T 细胞功能障碍。
Gastroenterology. 2010 Sep;139(3):770-8. doi: 10.1053/j.gastro.2010.06.006. Epub 2010 Jun 9.
引用本文的文献
1
Inborn errors of regulatory T-cell differentiation and function.调节性T细胞分化和功能的先天性缺陷。
J Allergy Clin Immunol. 2025 Jul 7. doi: 10.1016/j.jaci.2025.07.001.
2
Comprehensive insights into pathogenesis, diagnosis, treatment, and prognosis in adult autoimmune enteropathy.对成人自身免疫性肠病的发病机制、诊断、治疗及预后的全面见解。
Orphanet J Rare Dis. 2025 May 2;20(1):208. doi: 10.1186/s13023-025-03731-2.
3
Pediatric autoimmune disorders with gastrointestinal expressions: from bench to bedside.儿科伴有胃肠道表现的自身免疫性疾病：从基础到临床。
Pathologica. 2022 Feb;114(1):32-39. doi: 10.32074/1591-951X-339. Epub 2021 Dec 2.
4
Intestinal Regulatory T Cells as Specialized Tissue-Restricted Immune Cells in Intestinal Immune Homeostasis and Disease.肠道调节性 T 细胞作为肠道免疫稳态和疾病中特化的组织限制性免疫细胞。
Front Immunol. 2021 Aug 4;12:716499. doi: 10.3389/fimmu.2021.716499. eCollection 2021.
5
IPEX Syndrome: Improved Knowledge of Immune Pathogenesis Empowers Diagnosis.免疫失调、多内分泌腺病、肠病、X连锁综合征（IPEX综合征）：对免疫发病机制的深入了解助力诊断。
Front Pediatr. 2021 Feb 22;9:612760. doi: 10.3389/fped.2021.612760. eCollection 2021.
6
Clinical Heterogeneity of Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome: A French Multicenter Retrospective Study.免疫失调、多内分泌腺病、肠病、X 连锁综合征的临床异质性：一项法国多中心回顾性研究。
Clin Transl Gastroenterol. 2018 Nov 2;9(10):201. doi: 10.1038/s41424-018-0064-x.
7
Regulation of actin-based apical structures on epithelial cells.上皮细胞中基于肌动蛋白的顶端结构的调节。
J Cell Sci. 2018 Oct 17;131(20):jcs221853. doi: 10.1242/jcs.221853.
8
Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis.调节性T细胞和叉头框蛋白3作为免疫稳态的调节因子
Front Immunol. 2017 May 26;8:605. doi: 10.3389/fimmu.2017.00605. eCollection 2017.
9
A Difficult and Rare Diagnosis of Autoimmune Enteropathy in a Patient Affected by Down Syndrome.一例唐氏综合征患者自身免疫性肠病的疑难罕见诊断。
J Clin Immunol. 2016 Jul;36(5):423-8. doi: 10.1007/s10875-016-0280-7. Epub 2016 Apr 12.
10
Patterns of Allergic Sensitization in High IgE Syndromes.高IgE综合征中的过敏致敏模式。
Curr Allergy Asthma Rep. 2015 Dec;15(12):70. doi: 10.1007/s11882-015-0574-5.
本文引用的文献
1
Treatment of pediatric autoimmune enteropathy with tacrolimus (FK506).他克莫司（FK506）治疗儿童自身免疫性肠病
Gastroenterology. 1996 Jul;111(1):237-43. doi: 10.1053/gast.1996.v111.pm8698205.
2
Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system.多发性硬化症：针对中枢神经系统中髓鞘的协同免疫攻击。
Cell. 1996 May 3;85(3):299-302. doi: 10.1016/s0092-8674(00)81107-1.
3
Insulin-dependent diabetes mellitus.胰岛素依赖型糖尿病
Cell. 1996 May 3;85(3):291-7. doi: 10.1016/s0092-8674(00)81106-x.
4
5
A Japanese family of X-linked auto-immune enteropathy with haemolytic anaemia and polyendocrinopathy.
Eur J Pediatr. 1993 Apr;152(4):313-5. doi: 10.1007/BF01956741.
6
Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type.使用重组人胰岛谷氨酸脱羧酶（GAD65）进行的定量测定表明，发病时64K自身抗体阳性可预测糖尿病类型。
J Clin Invest. 1993 Jan;91(1):368-74. doi: 10.1172/JCI116195.
7
Familial autoimmune enteropathy with circulating anti-bullous pemphigoid antibodies and chronic autoimmune hepatitis.
J Pediatr. 1994 Dec;125(6 Pt 1):858-62. doi: 10.1016/s0022-3476(05)81999-7.
8
Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.胰岛素依赖型糖尿病中对谷氨酸脱羧酶和柯萨奇病毒共同抗原决定簇的细胞免疫。
J Clin Invest. 1994 Nov;94(5):2125-9. doi: 10.1172/JCI117567.
9
Autoimmune enteropathy with anti-goblet cell antibodies.
Hum Pathol. 1995 Oct;26(10):1162-8. doi: 10.1016/0046-8177(95)90283-x.
10
Combination therapy with tacrolimus and betamethasone for a patient with X-linked auto-immune enteropathy.他克莫司与倍他米松联合治疗一名X连锁自身免疫性肠病患者。
Eur J Pediatr. 1995 Jul;154(7):594-5. doi: 10.1007/BF02074852.
Zotero 插件