溃疡性结肠炎（UC）患者血清可溶性CD30水平升高，但克罗恩病（CD）患者血清可溶性CD30水平未升高。
Serum levels of soluble CD30 are increased in ulcerative colitis (UC) but not in Crohn's disease (CD).
作者信息
Giacomelli R, Passacantando A, Parzanese I, Vernia P, Klidara N, Cucinelli F, Lattanzio R, Santori E, Cipriani P, Caprilli R, Tonietti G
机构信息
Clinica Medica, University of L'Aquila, Italy.
出版信息
Clin Exp Immunol. 1998 Mar;111(3):532-5. doi: 10.1046/j.1365-2249.1998.00532.x.
Abstract
Imbalance in Th1 and Th2 subsets and their derived cytokines seems to be involved in the immune abnormalities underlying UC and CD. CD30 is a member of the tumour necrosis factor/nerve growth receptor superfamily expressed on T cells producing Th2 cytokines and released as a soluble form. In this study high levels of soluble CD30 were found in sera of UC patients independently of disease activity. Furthermore, increased titres of soluble CD30 molecule were shown, in the same patients, by mitogen-stimulated cultures of peripheral blood mononuclear cells. Our data seem to indicate that an activation of Th2 immune response is involved in the pathogenesis of UC, but not of CD. Furthermore, this finding indicates that serum soluble CD30 measurement may be helpful for differentiating these two forms of inflammatory bowel disease.
摘要
Th1和Th2亚群及其衍生细胞因子的失衡似乎与溃疡性结肠炎（UC）和克罗恩病（CD）潜在的免疫异常有关。CD30是肿瘤坏死因子/神经生长受体超家族的成员，表达于产生Th2细胞因子的T细胞上，并以可溶性形式释放。在本研究中，UC患者血清中发现高水平的可溶性CD30，且与疾病活动无关。此外，在相同患者中，外周血单个核细胞经丝裂原刺激培养后，可溶性CD30分子的滴度增加。我们的数据似乎表明，Th2免疫反应的激活参与了UC的发病机制，但不参与CD的发病机制。此外，这一发现表明，检测血清可溶性CD30可能有助于区分这两种炎症性肠病。
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