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Infect Immun. 1998 Apr;66(4):1800-2. doi: 10.1128/IAI.66.4.1800-1802.1998.
2
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Leptin: at the crossroads of energy balance and systemic inflammation.瘦素：处于能量平衡与全身炎症的交叉点
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细菌性腹膜炎小鼠中瘦素表达的增加部分受肿瘤坏死因子α调控。

Increased leptin expression in mice with bacterial peritonitis is partially regulated by tumor necrosis factor alpha.

作者信息

Moshyedi A K, Josephs M D, Abdalla E K, Mackay S L, Edwards C K, Copeland E M, Moldawer L L

机构信息

Department of Surgery, University of Florida College of Medicine, Gainesville 32610, USA.

出版信息

Infect Immun. 1998 Apr;66(4):1800-2. doi: 10.1128/IAI.66.4.1800-1802.1998.

DOI:10.1128/IAI.66.4.1800-1802.1998
PMID:9529118
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC108125/
Abstract

Plasma leptin and ob gene mRNA levels were increased in mice following bacterial peritonitis, and blocking an endogenous tumor necrosis factor alpha (TNF-alpha) response blunted the increase. However, plasma leptin concentrations did not correlate with the associated anorexia. We conclude that leptin expression is under partial regulatory control of TNF-alpha in peritonitis, but the anorexia is not dependent on increased leptin production.

摘要

细菌性腹膜炎后小鼠血浆瘦素和ob基因mRNA水平升高，阻断内源性肿瘤坏死因子α（TNF-α）反应可减弱这种升高。然而，血浆瘦素浓度与相关的厌食症并无关联。我们得出结论，在腹膜炎中瘦素表达受TNF-α的部分调控，但厌食症并不依赖于瘦素产生的增加。