Miyake M, Kamo N, Kurihara K, Kobatake Y
Biochim Biophys Acta. 1976 Jul 15;436(4):843-55. doi: 10.1016/0005-2736(76)90411-9.
The model membrane composed of a Millipore filter paper and the total lipids from bovine tongue epithelium or phosphatidylcholine from egg yolk simulated well the water response of a living taste cell, The water response observed with the model membrane adapted to various salt solutions was interpreted in terms of changes in electric potential at the membrane-solution interface, i.e. the water response was attributed to the e.m.f. change produced by diffusion of the electrolytes dissolved in (or adsorbed on) the membrane surface into the bulk solution. The water response of the frog tongue was also investigated by measuring the neural response of the glossopharyngeal nerve. The results obtained were consistent with the mechanism proposed in the present paper. The response of the frog to Ca2+ was examined under the condition where the water response was suppressed, and it was concluded that the water response of the frog is different from the response to Ca2+.
由微孔滤纸以及来自牛舌上皮的总脂质或蛋黄中的磷脂酰胆碱组成的模型膜很好地模拟了活味觉细胞的水响应。用适应各种盐溶液的模型膜观察到的水响应是根据膜 - 溶液界面处的电势变化来解释的，即水响应归因于溶解在（或吸附在）膜表面的电解质扩散到本体溶液中所产生的电动势变化。还通过测量舌咽神经的神经响应来研究蛙舌的水响应。所获得的结果与本文提出的机制一致。在水响应受到抑制的条件下研究了蛙对Ca2+的响应，得出结论：蛙的水响应与对Ca2+的响应不同。
