一名使用去氨加压素治疗夜间遗尿症的儿童发生低钠血症性癫痫发作。
Hyponatremic seizure in a child using desmopressin for nocturnal enuresis.
作者信息
Donoghue M B, Latimer M E, Pillsbury H L, Hertzog J H
机构信息
Department of Pediatrics, Georgetown University Medical Center, Washington, DC, USA.
出版信息
Arch Pediatr Adolesc Med. 1998 Mar;152(3):290-2. doi: 10.1001/archpedi.152.3.290.
BACKGROUND
Intranasal desmopressin has been used extensively to treat primary nocturnal enuresis. While it has proven to be a safe, effective agent for many who are affected by this condition, the potential for complications exists.
OBJECTIVES
To report a case of severe hyponatremia associated with a generalized tonic-clonic seizure in a 10-year-old boy who had been receiving intranasal desmopressin nightly for nocturnal enuresis and to briefly review therapeutic options for nocturnal enuresis; and to present the role of desmopressin.
SETTING
Georgetown University Medical Center, Washington, DC.
INTERVENTION
Fluid restriction and intravenous isotonic saline solution with 5% dextrose was administered to raise the serum sodium level.
OUTCOME
Prevention of further seizures with normalization of serum sodium levels without any obvious neurological sequelae.
CONCLUSIONS
This case illustrates the importance of weighing the benefits and risks of intranasal desmopressin therapy.
背景
鼻内去氨加压素已被广泛用于治疗原发性夜间遗尿症。虽然它已被证明对许多受此病症影响的人来说是一种安全有效的药物，但仍存在并发症的可能性。
目的
报告一例10岁男孩因夜间遗尿每晚接受鼻内去氨加压素治疗后出现严重低钠血症并伴有全身性强直阵挛性发作的病例，并简要回顾夜间遗尿症的治疗选择；并阐述去氨加压素的作用。
地点
华盛顿特区乔治敦大学医学中心。
干预措施
实施液体限制，并给予含5%葡萄糖的静脉等渗盐溶液以提高血清钠水平。
结果
血清钠水平恢复正常，防止了进一步发作，且无任何明显的神经后遗症。
结论
本病例说明了权衡鼻内去氨加压素治疗的利弊的重要性。
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