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伴有神经功能缺损和脑脊液淋巴细胞增多的短暂性头痛综合征。1例无严重头痛的病例报告。

The transient syndrome of headache with neurologic deficits and CSF lymphocytosis. Report of a case without severe headache.

作者信息

Oldani A, Marcone A, Zamboni M, Zucconi M, Ferini-Strambi L

机构信息

Department of Neurology, University of Milano School of Medicine, Istituto Scientifico H San Raffaele, Italy.

出版信息

Headache. 1998 Feb;38(2):135-7. doi: 10.1046/j.1526-4610.1998.3802135.x.

DOI:10.1046/j.1526-4610.1998.3802135.x
PMID:9529771
Abstract

It has been recently reported that the occurrence of severe headache associated with temporary neurologic deficits and CSF lymphocytic pleocytosis is highly suggestive of the so-called "transient syndrome of headache with neurologic deficits and CSF lymphocytosis." In particular, in almost all of the 40 patients reported in the literature to date, the head pain was severe and of a type not previously experienced by the patient. In the present case report, we describe a patient who fulfilled almost all the proposed diagnostic criteria, except for the lack of a severe headache. Probably, a severe headache is not a compulsory feature of this syndrome. Some patients have rather mild headache accompanying their episodes of neurologic symptoms, and some attacks occur without any accompanying headache. It is possible that in some cases the absence of a severe headache, and thus the lack of CSF analysis, lead to misdiagnosis. Therefore, the prevalence of this syndrome could be underestimated.

摘要

最近有报道称,伴有短暂性神经功能缺损和脑脊液淋巴细胞增多的严重头痛的出现高度提示所谓的“伴有神经功能缺损和脑脊液淋巴细胞增多的短暂性头痛综合征”。特别是,在迄今为止文献报道的几乎所有40例患者中,头痛都很严重,且是患者以前未曾经历过的类型。在本病例报告中,我们描述了一名几乎符合所有提出的诊断标准的患者,只是没有严重头痛。可能,严重头痛并非该综合征的必备特征。一些患者在出现神经症状发作时伴有相当轻微的头痛,还有一些发作时没有任何伴随的头痛。在某些情况下,可能由于没有严重头痛,进而没有进行脑脊液分析,导致误诊。因此,该综合征的患病率可能被低估。

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引用本文的文献

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Confusional state as first symptom of HaNDL syndrome.意识模糊状态作为短暂性局灶性神经症状伴淋巴细胞增多综合征(HaNDL综合征)的首发症状
Neurol Sci. 2015 May;36 Suppl 1:71-4. doi: 10.1007/s10072-015-2194-1.
2
Syndrome of transient Headache and Neurological Deficits with cerebrospinal fluid Lymphocytosis (HaNDL).伴有脑脊液淋巴细胞增多的短暂性头痛和神经功能缺损综合征(HaNDL)
BMJ Case Rep. 2011 Mar 29;2011:bcr0320102862. doi: 10.1136/bcr.03.2010.2862.