Loesche W J, Schork A, Terpenning M S, Chen Y M, Dominguez B L, Grossman N
University of Michigan, School of Dentistry, Department of Biologic and Materials Science, Ann Arbor 48109-1078, USA.
J Am Dent Assoc. 1998 Mar;129(3):301-11. doi: 10.14219/jada.archive.1998.0204.
Several recent studies have shown a link between dental disease and coronary heart disease. The authors studied 320 U.S. veterans in a convenience sample to assess the relationship between oral health and systemic diseases among older people. They present cross-sectional data confirming that a statistically significant association exists between a diagnosis of coronary heart disease and certain oral health parameters, such as the number of missing teeth, plaque benzoyl-DL-arginine-naphthylamide test scores, salivary levels of Streptococcus sanguis and complaints of xerostomia. The oral parameters in these subjects were independent of and more strongly associated with coronary heart disease than were recognized risk factors, such as serum cholesterol levels, body mass index, diabetes and smoking status. However, because of the convenience sample studied, these findings cannot be generalized to other populations.
最近的几项研究表明，牙齿疾病与冠心病之间存在联系。作者对320名美国退伍军人进行了便利抽样研究，以评估老年人口腔健康与全身性疾病之间的关系。他们提供的横断面数据证实，冠心病诊断与某些口腔健康参数之间存在统计学上的显著关联，如缺牙数量、菌斑苯甲酰-DL-精氨酸-萘酰胺试验得分、血链球菌唾液水平和口干症状。这些受试者的口腔参数与冠心病独立相关，且比血清胆固醇水平、体重指数、糖尿病和吸烟状况等公认的风险因素与冠心病的关联更强。然而，由于所研究的是便利样本，这些发现不能推广到其他人群。
