Lang P J, Bradley M M, Fitzsimmons J R, Cuthbert B N, Scott J D, Moulder B, Nangia V
University of Florida, Gainesville 32610, USA.
Psychophysiology. 1998 Mar;35(2):199-210.
Functional activity in the visual cortex was assessed using functional magnetic resonance imaging technology while participants viewed a series of pleasant, neutral, or unpleasant pictures. Coronal images at four different locations in the occipital cortex were acquired during each of eight 12-s picture presentation periods (on) and 12-s interpicture interval (off). The extent of functional activation was larger in the right than the left hemisphere and larger in the occipital than in the occipitoparietal regions during processing of all picture contents compared with the interpicture intervals. More importantly, functional activity was significantly greater in all sampled brain regions when processing emotional (pleasant or unpleasant) pictures than when processing neutral stimuli. In Experiment 2, a hypothesis that these differences were an artifact of differential eye movements was ruled out. Whereas both emotional and neutral pictures produced activity centered on the calcarine fissure (Area 17), only emotional pictures also produced sizable clusters bilaterally in the occipital gyrus, in the right fusiform gyrus, and in the right inferior and superior parietal lobules.
在参与者观看一系列愉悦、中性或不愉快的图片时，使用功能磁共振成像技术评估视觉皮层的功能活动。在八个12秒的图片呈现期（开启）和12秒的图片间隔期（关闭）中的每一个期间，采集枕叶皮质四个不同位置的冠状图像。与图片间隔期相比，在处理所有图片内容时，右侧半球的功能激活范围大于左侧半球，枕叶的功能激活范围大于枕顶叶区域。更重要的是，与处理中性刺激相比，在处理情绪性（愉悦或不愉快）图片时，所有采样脑区的功能活动显著更强。在实验2中，排除了这些差异是不同眼球运动造成的假象这一假设。虽然情绪性和中性图片都产生了以距状裂（17区）为中心活动，但只有情绪性图片还在枕回、右侧梭状回以及右侧顶叶上下小叶双侧产生了相当大的簇状活动。
