Scammell T E, Griffin J D, Elmquist J K, Saper C B
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Am J Physiol. 1998 Mar;274(3):R783-9. doi: 10.1152/ajpregu.1998.274.3.R783.
Considerable evidence supports the role of prostaglandins in fever production, but the neuroanatomic sites of prostaglandin synthesis that produce fever remain unknown. With the use of a novel microinjection technique, we injected the cyclooxygenase inhibitor ketorolac into the preoptic area (POA) to determine which preoptic regions produce the prostaglandins required for fever. Initial experiments demonstrated that intravenous ketorolac blocked the fever normally produced by lipopolysaccharide (LPS) 5 micrograms/kg i.v. Microinjection of ketorolac into the POA had no effect on body temperature, and injection of artificial cerebrospinal fluid into the POA did not alter LPS fever. Injection of ketorolac into the anteroventral POA markedly decreased the fever produced by LPS, compared with injections into more rostral, caudal, or dorsal locations. These observations indicate that prostaglandin synthesis in the anteroventral preoptic region is necessary for the production of fever.
大量证据支持前列腺素在发热产生中的作用，但产生发热的前列腺素合成的神经解剖部位尚不清楚。我们使用一种新型微注射技术，将环氧化酶抑制剂酮咯酸注入视前区（POA），以确定哪些视前区产生发热所需的前列腺素。初步实验表明，静脉注射酮咯酸可阻断通常由5微克/千克静脉注射脂多糖（LPS）引起的发热。将酮咯酸微注射到视前区对体温没有影响，而将人工脑脊液注射到视前区不会改变LPS引起的发热。与注射到更靠前、靠后或靠背位置相比，将酮咯酸注射到腹侧前视前区可显著降低LPS引起的发热。这些观察结果表明，腹侧前视前区的前列腺素合成是发热产生所必需的。
