Limon J, Babińska M, Denis A, Ryś J, Niezabitowski A
Department of Biology and Genetics, Medical University of Gdańsk, Poland.
Cancer Genet Cytogenet. 1998 Apr 1;102(1):78-80. doi: 10.1016/s0165-4608(97)00270-7.
This is the first report on clonal chromosomal aberrations in a metastatic parachordoma lesion. All neoplastic cells had the karyotype 33-47,X,der(X)t(X;3) (p11;p11),der(3)t(3;6)(p11;q13), del(6)(q13), -9, -13,r(13), +mar. The presence of t(X;3) with a breakpoint at band Xp11 as in synovial sarcoma may suggest a common histological origin of the two tumor types.
这是关于转移性副脊索瘤病变中克隆性染色体畸变的首篇报告。所有肿瘤细胞的核型为33 - 47,X,der(X)t(X;3)(p11;p11),der(3)t(3;6)(p11;q13), del(6)(q13), -9, -13,r(13), +mar。如滑膜肉瘤那样在Xp11带存在断点的t(X;3)，可能提示这两种肿瘤类型有共同的组织学起源。
