Guobadia E E, Fagbemi B O, Oyejide A
Department of Veterinary Microbiology and Parasitology, University of Ibadan, Nigeria.
Afr J Med Med Sci. 1996 Dec;25(4):347-52.
Heterologous humoral and cellular immune response to Schistosoma mansoni and S. bovis antigens were investigated in Tryponosoma gambiense-infected mice in order to understand the concurrent immune response to both parasites. Immune response as measured by the Indirect Haemagglutination Test (IHA), Spontaneous sheep red blood cell rosette formation with B-lymphocytes and the mean number of T-lymphocytes forming rosettes with AET-treated SRBC to the schistosome antigens, was significantly depressed in the trypanosome-infected mice. Furthermore, the timing of trypanosome infection and the inoculation of antigen was related to the degree of immunosuppression as animals which had trypanosome infection and the whole worm antigen of S. mansoni and S. bovis simultaneously had higher IHA titre than those which were inoculated with the antigens 10 days after the commencement of an infection. The results are discussed from the viewpoint of immunological control of schistosomiasis in areas where both diseases are endemic.
为了解冈比亚锥虫感染小鼠对曼氏血吸虫和牛血吸虫抗原的异源体液免疫和细胞免疫反应，对其进行了研究，以了解对这两种寄生虫的同时免疫反应。通过间接血凝试验（IHA）、B淋巴细胞自发形成绵羊红细胞花环以及与经AET处理的SRBC形成花环的T淋巴细胞平均数来衡量的对血吸虫抗原的免疫反应，在锥虫感染小鼠中显著降低。此外，锥虫感染的时间和抗原接种与免疫抑制程度有关，因为同时感染锥虫以及接种曼氏血吸虫和牛血吸虫全虫抗原的动物，其IHA滴度高于感染开始10天后接种抗原的动物。从这两种疾病流行地区血吸虫病免疫控制的角度对结果进行了讨论。
