Bykov I L
Klin Lab Diagn. 1998 Jan(1):15-9.
Gas liquid chromatography (GLC) remains the most efficient method for analysis of organic acids in biological fluids. This paper presents a GLC method for measuring organic acids in the urine. Our method of extraction and GLC of trimethylsilyl derivatives of organic acids is a specific and highly sensitive procedure which permits investigation of the complex spectrum of organic acids, including aliphatic oxocarbonic, dicarbonic, hydroxycarbonic, and aromatic acids and glycine conjugates in the urine and other physiological fluids. It can be used for the diagnosis and prenatal screening of hereditary and acquired metabolic disorders.
气相液相色谱法（GLC）仍然是分析生物体液中有机酸最有效的方法。本文介绍了一种用于测量尿液中有机酸的GLC方法。我们对有机酸三甲基硅烷基衍生物进行萃取和GLC分析的方法是一种特异且高度灵敏的程序，它能够对包括脂肪族含氧酸、二元羧酸、羟基羧酸、芳香酸以及尿液和其他生理体液中的甘氨酸共轭物在内的复杂有机酸谱进行研究。该方法可用于遗传性和获得性代谢紊乱的诊断及产前筛查。
