Meier-Augenstein W, Hoffmann G F, Holmes B, Jones J L, Nyhan W L, Sweetman L
Abteilung Neuropädiatrie, Universitäts-Kinderklinik, Heidelberg, Germany.
J Chromatogr. 1993 May 19;615(1):127-35. doi: 10.1016/0378-4347(93)80298-i.
An improved method for the identification and quantification of organic acids in body fluids employing capillary gas chromatography-mass spectrometry has been developed. A thick-film capillary column, that combines the properties of a capillary column with those of a megabore column, has been successfully introduced into an existing method. Analysis over a concentration range from 1 mumol/l to 500 mumol/l body fluid is possible. This permits the assay of samples that are usually obtained in small volumes, e.g. cerebrospinal fluid.
