Whittall J T, Parkhouse R M
Institute for Animal Health, Pirbright Laboratory, Pirbright, Surrey, UK.
Vet Immunol Immunopathol. 1997 Dec 12;60(1-2):149-60. doi: 10.1016/s0165-2427(97)00123-2.
Monoclonal antibodies recognising swine leucocyte antigens were identified and the corresponding antigens were characterised by determining their tissue distribution and molecular weight as well as immunohistochemical staining. On the basis of these data, we suggest that two antibodies are specific for a molecules within a porcine orthologue of one of the human CDII/CD18 complexes. We suggest that two others recognise swine wCD21, that one may recognise swine wCD6 and that another recognises an antigen designated by the International Swine CD Workshop cluster SWC9. Other antibodies were obtained which are specific for swine macrophages or B cells, but CD or cluster assignments for these antigens have not been made. Detailed analysis of the antibodies is presented. It is proposed that these antibodies will be useful in studies of the pig immune system and of virus infection.
识别猪白细胞抗原的单克隆抗体被鉴定出来，通过确定相应抗原的组织分布、分子量以及免疫组织化学染色对其进行了表征。基于这些数据，我们认为有两种抗体对人CD11/CD18复合体之一的猪直系同源分子内的一种分子具有特异性。我们认为另外两种抗体识别猪wCD21，一种可能识别猪wCD6，另一种识别由国际猪CD研讨会集群SWC9指定的一种抗原。还获得了对猪巨噬细胞或B细胞具有特异性的其他抗体，但尚未对这些抗原进行CD或集群分类。文中对这些抗体进行了详细分析。建议这些抗体将有助于猪免疫系统和病毒感染的研究。
