Saalmüller A, Pauly T, Lunney J K, Boyd P, Aasted B, Sachs D H, Arn S, Bianchi A, Binns R M, Licence S, Whyte A, Blecha F, Chen Z, Chu R M, Davis W C, Denham S, Yang H, Whittall T, Parkhouse R M, Dominguez J, Ezquerra A, Alonso F, Horstick G, Howard C, Zuckermann F
Federal Research Centre for Virus Diseases of Animals, Tübingen, Germany.
Vet Immunol Immunopathol. 1998 Jan 30;60(3-4):207-28. doi: 10.1016/s0165-2427(97)00098-6.
The aim of the Second International Swine Cluster of Differentiation (CD) Workshop, supported by the Veterinary Immunology Committee (VIC) of the International Union of Immunological Societies (IUIS), was to standardize the assignment of monoclonal antibodies (mAb) reactive with porcine leukocyte differentiation antigens and to define new antibody clusters. At the summary meeting of the workshop in July, 1995, revisions in the existing nomenclature for Swine CD were approved, so that the rules are now in accord with those for human and ruminant CD. Swine CD numbers will now be given to clusters of mAb to swine orthologues of human CD molecules when homology is proven by (1) suitable tissue distribution and lymphoid cell subset expression, (2) appropriate molecular mass of the antigen recognized by the mAbs, and (3) reactivity of mAbs with the cloned swine gene products, or cross-reactivity of the mAb on the human gene products. In some cases, this reactivity would not be fully proven, mainly due to the lack of cloned gene products; for these CD antigens, the respective clusters will be assigned by the prefix 'w' which will lead to 'wCD' antigens. As a result of the Second International Swine CD Workshop the assignment of 16 mAb to existing CD groups (CD2a, CD4a, CD5a, wCD6, wCD8, CD14, CD18a, wCD21, wCD25) was confirmed, and 2 mAb to existing swine workshop clusters (SWC). More importantly, for the work on the porcine immune system, was the definition of 5 new swine CD antigens, namely CD3 (recognized by 6 new mAb and 3 epitopes), CD16 (1 new mAb), wCD29 (2 mAb), CD45RA (3 mAb) and CD45RC (1 new mAb). Finally, the demarcation of two new SWC molecules in swine, SWC8 (2 mAb) and SWC9 (2 mAb) was confirmed.
由国际免疫学会兽医免疫学委员会（VIC）支持的第二届国际猪分化簇（CD）研讨会的目的是规范与猪白细胞分化抗原反应的单克隆抗体（mAb）的指定，并定义新的抗体簇。在1995年7月的研讨会总结会议上，对猪CD现有命名法的修订获得批准，因此现在的规则与人类和反刍动物CD的规则一致。当通过以下方式证明同源性时，猪CD编号现在将赋予与人类CD分子的猪直系同源物的mAb簇：（1）合适的组织分布和淋巴细胞亚群表达；（2）mAb识别的抗原的适当分子量；（3）mAb与克隆的猪基因产物的反应性，或mAb对人类基因产物的交叉反应性。在某些情况下，这种反应性无法得到充分证明，主要是由于缺乏克隆的基因产物；对于这些CD抗原，相应的簇将被赋予前缀“w”，这将产生“wCD”抗原。作为第二届国际猪CD研讨会的结果，确认将16种mAb分配到现有的CD组（CD2a、CD4a、CD5a）、wCD6、wCD8、CD14、CD18a、wCD21、wCD25），并将2种mAb分配到现有的猪研讨会簇（SWC）。更重要的是，对于猪免疫系统的研究，定义了5种新的猪CD抗原，即CD3（由6种新mAb和3个表位识别）、CD16（1种新mAb）、wCD29（2种mAb）、CD45RA（3种mAb）和CD45RC（1种新mAb）。最后，确认了猪中两个新的SWC分子SWC8（2种mAb）和SWC9（2种mAb）的划分。
