Lin C C, Yen M H, Lo T S, Lin J M
Graduate Institute of Natural Products, Kaohsiung Medical College, Taiwan, ROC.
J Ethnopharmacol. 1998 Feb;60(1):9-17. doi: 10.1016/s0378-8741(97)00122-0.
In this study, the relationship between liver protective effects and antioxidant activity of Boehmeria nivea var. nivea (= B. nivea) and B. nivea var. tenacissima (= B. frutescens) was investigated. The water extracts of both plants exhibited a hepatoprotective activity against CCl4-induced liver injury. B. nivea var. nivea and B. nivea var. tenacissima, also showed anti-oxidant effects in FeCl2-ascorbate induced lipid peroxidation in rat liver homogenate. Moreover, the active oxygen species scavenging potencies were evaluated by an electron spin resonance (ESR) spin-trapping technique. B. nivea var. tenacissima displayed better superoxide radical scavenging activity than B. nivea. Based on these findings, we suggest that in the liver protective and antioxidative effects of B. nivea var. nivea and B. nivea var. tenacissima, possibly involve mechanisms related to free radical scavenging effects.
在本研究中，对苎麻（= 苎麻）和苎麻变种（= 苘麻）的肝脏保护作用与抗氧化活性之间的关系进行了研究。两种植物的水提取物均对四氯化碳诱导的肝损伤表现出肝脏保护活性。苎麻和苘麻在氯化亚铁 - 抗坏血酸诱导的大鼠肝脏匀浆脂质过氧化中也表现出抗氧化作用。此外，通过电子自旋共振（ESR）自旋捕获技术评估了活性氧清除能力。苘麻显示出比苎麻更好的超氧自由基清除活性。基于这些发现，我们认为苎麻和苘麻的肝脏保护和抗氧化作用可能涉及与自由基清除作用相关的机制。
