• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

果蝇叉状蛋白的抑制因子，是mRNA 3'末端形成所需的人类77K蛋白的同源物，在有丝分裂活跃的细胞中积累。

The suppressor of forked protein of Drosophila, a homologue of the human 77K protein required for mRNA 3'-end formation, accumulates in mitotically-active cells.

作者信息

Audibert A, Juge F, Simonelig M

机构信息

Dynamique du Génome et Evolution, Institut Jacques Monod, Université Denis Diderot, 2, Place Jussieu, 75005, Paris, France.

出版信息

Mech Dev. 1998 Mar;72(1-2):53-63. doi: 10.1016/s0925-4773(98)00017-3.

DOI:10.1016/s0925-4773(98)00017-3
PMID:9533952
Abstract

The suppressor of forked (Su(f)) protein of Drosophila melanogaster is highly homologous to two proteins involved in mRNA 3'-end formation, the yeast RNA14 protein and the 77K subunit of human cleavage stimulation factor (CstF). This suggests a role for su(f) in mRNA 3'-end-processing, probably as part of Drosophila CstF. We have investigated the expression pattern of su(f) during Drosophila development and found that the su(f) gene product is not detected ubiquitously. The Su(f) protein accumulates in mitotically-active cells, but does not in non-dividing cells. This expression pattern corroborates earlier data suggesting that the phenotypes of su(f) mutants could result from a defect in cell proliferation. Our results suggest that, in Drosophila, Su(f) is involved in the regulatory function of CstF.

摘要

果蝇的叉状抑制因子（Su(f)）蛋白与参与mRNA 3'末端形成的两种蛋白高度同源，即酵母RNA14蛋白和人切割刺激因子（CstF）的77K亚基。这表明su(f)在mRNA 3'末端加工中发挥作用，可能是果蝇CstF的一部分。我们研究了su(f)在果蝇发育过程中的表达模式，发现su(f)基因产物并非在所有细胞中都能检测到。Su(f)蛋白在有丝分裂活跃的细胞中积累，但在非分裂细胞中则不积累。这种表达模式证实了早期的数据，表明su(f)突变体的表型可能是由于细胞增殖缺陷所致。我们的结果表明，在果蝇中，Su(f)参与了CstF的调节功能。

相似文献

1
The suppressor of forked protein of Drosophila, a homologue of the human 77K protein required for mRNA 3'-end formation, accumulates in mitotically-active cells.果蝇叉状蛋白的抑制因子，是mRNA 3'末端形成所需的人类77K蛋白的同源物，在有丝分裂活跃的细胞中积累。
Mech Dev. 1998 Mar;72(1-2):53-63. doi: 10.1016/s0925-4773(98)00017-3.
2
The suppressor of forked gene of Drosophila, which encodes a homologue of human CstF-77K involved in mRNA 3'-end processing, is required for progression through mitosis.果蝇的叉状基因抑制因子编码一种参与mRNA 3'末端加工的人类CstF - 77K同源物，它是有丝分裂进程所必需的。
Mech Dev. 1999 Apr;82(1-2):41-50. doi: 10.1016/s0925-4773(99)00011-8.
3
Chimeric human CstF-77/Drosophila Suppressor of forked proteins rescue suppressor of forked mutant lethality and mRNA 3' end processing in Drosophila.嵌合的人CstF-77/果蝇叉状蛋白抑制因子可挽救果蝇中叉状突变体致死性并参与mRNA 3'末端加工。
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10593-8. doi: 10.1073/pnas.162191899. Epub 2002 Jul 29.
4
Tissue-specific autoregulation of Drosophila suppressor of forked by alternative poly(A) site utilization leads to accumulation of the suppressor of forked protein in mitotically active cells.通过可变聚腺苷酸化位点利用对果蝇叉状抑制因子进行组织特异性自调控，导致叉状抑制因子蛋白在有丝分裂活跃细胞中积累。
RNA. 2000 Nov;6(11):1529-38. doi: 10.1017/s1355838200001266.
5
A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein.一种聚腺苷酸化因子亚基是果蝇叉状蛋白抑制因子的人类同源物。
Nature. 1994 Dec 1;372(6505):471-4. doi: 10.1038/372471a0.
6
Autoregulation at the level of mRNA 3' end formation of the suppressor of forked gene of Drosophila melanogaster is conserved in Drosophila virilis.果蝇黑腹果蝇叉状基因抑制因子mRNA 3'末端形成水平的自调控在果蝇属中是保守的。
Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14302-7. doi: 10.1073/pnas.95.24.14302.
7
The Drosophila homologue of the 64 kDa subunit of cleavage stimulation factor interacts with the 77 kDa subunit encoded by the suppressor of forked gene.切割刺激因子64 kDa亚基的果蝇同源物与叉状基因抑制子编码的77 kDa亚基相互作用。
Nucleic Acids Res. 2000 Jan 15;28(2):520-6. doi: 10.1093/nar/28.2.520.
8
Characterization of a Drosophila homologue of the 160-kDa subunit of the cleavage and polyadenylation specificity factor CPSF.果蝇切割与聚腺苷酸化特异性因子CPSF 160-kDa亚基的同源物的特性分析
Mol Gen Genet. 1998 Apr;257(6):672-80. doi: 10.1007/s004380050696.
9
Developmental expression pattern of the Caenorhabditis elegans homologue of the Drosophila suppressor of forked gene.秀丽隐杆线虫中果蝇叉状基因抑制因子同源物的发育表达模式。
DNA Res. 1995 Jun 30;2(3):143-6. doi: 10.1093/dnares/2.3.143.
10
Elimination of introns at the Drosophila suppressor-of-forked locus by P-element-mediated gene conversion shows that an RNA lacking a stop codon is dispensable.通过P因子介导的基因转换消除果蝇叉状抑制基因座处的内含子表明，缺少终止密码子的RNA是可有可无的。
Genetics. 1996 May;143(1):345-51. doi: 10.1093/genetics/143.1.345.

引用本文的文献

1
The Green Valley of   Constitutive Heterochromatin: Protein-Coding Genes Involved in Cell Division Control.组成性异染色质的绿色峡谷：参与细胞分裂控制的蛋白质编码基因。
Cells. 2022 Sep 29;11(19):3058. doi: 10.3390/cells11193058.
2
Chimeric human CstF-77/Drosophila Suppressor of forked proteins rescue suppressor of forked mutant lethality and mRNA 3' end processing in Drosophila.嵌合的人CstF-77/果蝇叉状蛋白抑制因子可挽救果蝇中叉状突变体致死性并参与mRNA 3'末端加工。
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10593-8. doi: 10.1073/pnas.162191899. Epub 2002 Jul 29.
3
Tissue-specific autoregulation of Drosophila suppressor of forked by alternative poly(A) site utilization leads to accumulation of the suppressor of forked protein in mitotically active cells.
通过可变聚腺苷酸化位点利用对果蝇叉状抑制因子进行组织特异性自调控，导致叉状抑制因子蛋白在有丝分裂活跃细胞中积累。
RNA. 2000 Nov;6(11):1529-38. doi: 10.1017/s1355838200001266.
4
Regulation of human papillomavirus type 31 polyadenylation during the differentiation-dependent life cycle.人乳头瘤病毒31型在依赖分化的生命周期中多聚腺苷酸化的调控
J Virol. 1999 Sep;73(9):7185-92. doi: 10.1128/JVI.73.9.7185-7192.1999.
5
Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis.真核生物中mRNA 3'末端的形成：机制、调控及其与mRNA合成其他步骤的相互关系
Microbiol Mol Biol Rev. 1999 Jun;63(2):405-45. doi: 10.1128/MMBR.63.2.405-445.1999.
6
Autoregulation at the level of mRNA 3' end formation of the suppressor of forked gene of Drosophila melanogaster is conserved in Drosophila virilis.果蝇黑腹果蝇叉状基因抑制因子mRNA 3'末端形成水平的自调控在果蝇属中是保守的。
Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14302-7. doi: 10.1073/pnas.95.24.14302.