Mouloudi H, Katsanoulas C, Frantzeskos G
Anaesthesiology Department, University Hospital of Heraklion, Crete, Greece.
Anaesthesia. 1998 Feb;53(2):177-80. doi: 10.1046/j.1365-2044.1998.00233.x.
Friedreich's ataxia is an inherited disorder of the nervous system, requiring special care during anaesthesia, because of increased sensitivity to muscle relaxants. We report a case of Friedreich's ataxia in a 31-year-old woman, anaesthetised on two occasions, for tendinoplasty and pes cavus repair. Atracurium was used for neuromuscular blockade and monitored by a train-of-four twitch technique. The patient's response was normal. She returned to adequate spontaneous breathing within 20 min of the last dose of the muscle relaxant without need for anticholinesterase administration. When neuromuscular function is monitored, normal doses of muscle relaxant can safely be used in these patients.
弗里德赖希共济失调是一种遗传性神经系统疾病，由于对肌肉松弛剂敏感性增加，麻醉期间需要特别护理。我们报告一例31岁女性弗里德赖希共济失调患者，该患者接受了两次麻醉，分别用于肌腱成形术和高弓足修复术。使用阿曲库铵进行神经肌肉阻滞，并通过四个成串刺激技术进行监测。患者反应正常。在最后一剂肌肉松弛剂使用后20分钟内，她恢复了充分的自主呼吸，无需使用抗胆碱酯酶药物。当监测神经肌肉功能时，这些患者可以安全使用正常剂量的肌肉松弛剂。
