Aguado F, Majó G, Gómez de Aranda I, Ferrer I
Departament de Biologia Cel.lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Spain.
Neurosci Lett. 1998 Feb 27;243(1-3):13-6. doi: 10.1016/s0304-3940(98)00074-3.
Several lines of evidence suggest that neurotrophins may be involved in pituitary function. By immunocytochemical methods we analyzed the cellular distribution of their functional receptors in the pituitary gland. In the rat pituitary gland Trks were differentially distributed. Punctate immunoreactivity for TrkA was observed within the neural lobe, whereas numerous nerve endings were immunostained for TrkB and TrkC in the intermediate lobe. Endocrine cells of the intermediate lobe exhibited intense immunoreactivity for the three Trks, whereas scattered endocrine cells of the anterior lobe displayed a robust immunostaining for TrkC. In addition, TrkA and TrkB immunoreactivity was located in normal and neoplastic endocrine cells from human pituitary adenomas. The differential distribution of Trks in the hypophysis suggests a potential role of different neurotrophins in pituitary functions.
多项证据表明神经营养因子可能参与垂体功能。我们采用免疫细胞化学方法分析了其功能性受体在垂体中的细胞分布。在大鼠垂体中，Trks呈差异性分布。在神经叶内观察到TrkA的点状免疫反应性，而在中间叶有大量神经末梢对TrkB和TrkC呈免疫染色。中间叶的内分泌细胞对三种Trks均表现出强烈的免疫反应性，而前叶散在的内分泌细胞对TrkC呈现出强烈的免疫染色。此外，TrkA和TrkB免疫反应性存在于人类垂体腺瘤的正常和肿瘤性内分泌细胞中。Trks在垂体中的差异性分布提示不同神经营养因子在垂体功能中可能发挥作用。
