Wiechens B, Schröder J O, Pötzsch B, Rochels R
Department of Ophthalmology, Christian-Albrechts-University, Kiel, Germany.
Am J Ophthalmol. 1997 Jun;123(6):848-50. doi: 10.1016/s0002-9394(14)71142-0.
To report a 31-year-old healthy patient with retinal venous occlusion in his left eye attributable to primary antiphospholipid antibody syndrome.
The patient was examined clinically. Multiple serologic and clinical investigations were performed to determine the causative disease. He was closely followed up for more than 3 years.
The presence of lupus anticoagulant in our patient was indicated by a kaolin clotting time index of 27 (normal, <17) and confirmed by the demonstration of IgG antibodies against phospholipids. After long-term oral anticoagulant treatment for 2 years, lupus anticoagulant levels returned to normal, and therapy was stopped. No further thrombotic event occurred during follow-up.
In retinal vascular occlusions of unexplained origin, antiphospholipid antibodies may play an important role in the pathogenesis. Detecting these antibodies in the serum of patients with retinal vascular occlusion helps determine the appropriate treatment with long-term oral anticoagulants.
报告一名31岁的健康患者，其左眼视网膜静脉阻塞归因于原发性抗磷脂抗体综合征。
对该患者进行了临床检查。进行了多项血清学和临床检查以确定病因疾病。对他进行了3年多的密切随访。
我们患者的高岭土凝血时间指数为27（正常，<17），表明存在狼疮抗凝物，并通过针对磷脂的IgG抗体的检测得到证实。经过2年的长期口服抗凝治疗，狼疮抗凝物水平恢复正常，治疗停止。随访期间未发生进一步的血栓形成事件。
在不明原因的视网膜血管阻塞中，抗磷脂抗体可能在发病机制中起重要作用。在视网膜血管阻塞患者的血清中检测这些抗体有助于确定长期口服抗凝剂的适当治疗。
