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衰老、健康风险与累积性残疾。

Aging, health risks, and cumulative disability.

作者信息

Vita A J, Terry R B, Hubert H B, Fries J F

机构信息

Department of Medicine, Stanford University School of Medicine, Calif, USA.

出版信息

N Engl J Med. 1998 Apr 9;338(15):1035-41. doi: 10.1056/NEJM199804093381506.

Abstract

BACKGROUND

Persons with lower health risks tend to live longer than those with higher health risks, but there has been concern that greater longevity may bring with it greater disability. We performed a longitudinal study to determine whether persons with lower potentially modifiable health risks have more or less cumulative disability.

METHODS

We studied 1741 university alumni who were surveyed first in 1962 (average age, 43 years) and then annually starting in 1986. Strata of high, moderate, and low risk were defined on the basis of smoking, body-mass index, and exercise patterns. Cumulative disability was determined with a health-assessment questionnaire and scored on a scale of 0 to 3. Cumulative disability from 1986 to 1994 (average age in 1994, 75 years) or death was the measure of lifetime disability.

RESULTS

Persons with high health risks in 1962 or 1986 had twice the cumulative disability of those with low health risks (disability index, 1.02 vs. 0.49; P<0.001). The results were consistent among survivors, subjects who died, men, and women and for both the last year and the last two years of observation. The onset of disability was postponed by more than five years in the low-risk group as compared with the high-risk group. The disability index for the low-risk subjects who died was half that for the high-risk subjects in the last one or two years of observation.

CONCLUSIONS

Smoking, body-mass index, and exercise patterns in midlife and late adulthood are predictors of subsequent disability. Not only do persons with better health habits survive longer, but in such persons, disability is postponed and compressed into fewer years at the end of life.

摘要

背景

健康风险较低的人往往比健康风险较高的人寿命更长,但有人担心更长的寿命可能会带来更多的残疾。我们进行了一项纵向研究,以确定具有较低潜在可改变健康风险的人累积残疾是更多还是更少。

方法

我们研究了1741名大学毕业生,他们于1962年首次接受调查(平均年龄43岁),然后从1986年开始每年接受调查。根据吸烟、体重指数和运动模式定义高、中、低风险分层。通过健康评估问卷确定累积残疾情况,并在0至3的量表上评分。1986年至1994年(1994年平均年龄75岁)的累积残疾或死亡是衡量终身残疾的指标。

结果

1962年或1986年健康风险高的人累积残疾是健康风险低的人的两倍(残疾指数分别为1.02和0.49;P<0.001)。在幸存者、死亡者、男性和女性中,以及在观察的最后一年和最后两年,结果都是一致的。与高风险组相比,低风险组残疾的 onset 推迟了五年以上。在观察的最后一两年中,死亡的低风险受试者的残疾指数是高风险受试者的一半。

结论

中年和成年后期的吸烟、体重指数和运动模式是随后残疾的预测因素。不仅健康习惯较好的人寿命更长,而且在这些人中,残疾被推迟并压缩到生命末期的较少年份。

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