Alonso-Llamazares J, De Pablo P, Ballestín C, Guerra A, Iglesias L
Department of Dermatology, Hospital 12 de Octubre, Madrid, Spain.
Br J Dermatol. 1998 Jan;138(1):145-9. doi: 10.1046/j.1365-2133.1998.02042.x.
Cutaneous metastases of internal malignancies are very rare in children. In this group, neuroblastoma, leukaemia and lymphoma are the most common malignancies that may develop metastases or neoplastic infiltrates to the skin. Carcinomas have infrequently been reported in children, and cutaneous metastases from carcinoma in this group have not been described. A 10-year-old girl presented with an erythematous plaque on the left hemithorax. Histopathological findings revealed grouped signet-ring cells within the lumina of lymphatic vessels in the dermis. Immunohistochemical examination confirmed the epithelial origin of the tumour. Despite an exhaustive search, the primary site could not be determined. This exceptional observation is, to the best of our knowledge, the first report of cutaneous metastasis from occult carcinoma in a child.
儿童体内恶性肿瘤的皮肤转移非常罕见。在这一群体中，神经母细胞瘤、白血病和淋巴瘤是最常见的可能发生皮肤转移或肿瘤浸润的恶性肿瘤。儿童中癌的报道较少，且该群体中癌的皮肤转移尚未见描述。一名10岁女孩左侧半胸出现一个红斑性斑块。组织病理学检查发现真皮内淋巴管腔内有成团的印戒细胞。免疫组织化学检查证实肿瘤起源于上皮。尽管进行了详尽的检查，仍无法确定原发部位。据我们所知，这一特殊病例是儿童隐匿性癌皮肤转移的首例报道。
