Fleming C, Lucke T, Forsyth A, Rees S, Lever R, Wray D, Aldridge R, MacKie R
University Department of Dermatology Western Infirmary, Glasgow, Scotland, UK.
Contact Dermatitis. 1998 Mar;38(3):137-9. doi: 10.1111/j.1600-0536.1998.tb05679.x.
1203 patients attending for routine patch testing at 3 hospitals and 105 volunteers were tested with 0.5% and 0.05% gold sodium thiosulfate (GST). 38 patients (3.2%) and 5 volunteers (4.8%) had positive patch tests to GST. There were no significant differences between volunteers and patients with respect to age, sex, atopy or exposure to gold in dental restorations, jewellery or through occupation. There were no significant differences in prevalence of GST hypersensitivity in the 3 hospitals, or between patients and controls. This is the 1st controlled study of hypersensitivity to GST, and suggests that routine patch testing to gold is of limited clinical benefit.
在3家医院接受常规斑贴试验的1203例患者和105名志愿者用0.5%和0.05%硫代硫酸钠金（GST）进行了测试。38例患者（3.2%）和5名志愿者（4.8%）对GST斑贴试验呈阳性。志愿者和患者在年龄、性别、特应性或在牙科修复体、珠宝中接触金或通过职业接触金方面没有显著差异。3家医院中GST超敏反应的患病率以及患者与对照组之间没有显著差异。这是第一项关于GST超敏反应的对照研究，表明对金进行常规斑贴试验的临床益处有限。
