Mustonen K, Mustakangas P, Smeds M, Mannonen L, Uotila L, Vaheri A, Koskiniemi M
Department of Neuropediatrics, North Karelia Central Hospital, Ioensu, Finland.
Arch Dis Child Fetal Neonatal Ed. 1998 Jan;78(1):F57-61. doi: 10.1136/fn.78.1.f57.
Four neonates with convulsions had IgG antibodies in their cerebrospinal fluid (CSF) to varicella zoster virus (VZV). These antibodies were found in the sera of two of these patients after the age of 6 months. Antibodies to 16 different microbes were studied from the serum and CSF of 201 neonates with neurological problems. The presence of DNA specific to HSV-1, HSV-2, and VZV in the CSF was also investigated using the polymerase chain reaction (PCR). Antibodies to VZV were detected in the CSF of four neonates. Antibody indices suggested production of VZV specific antibodies in the central nervous system. These findings suggest that intrathecal production of antibodies to VZV can appear in neonates with neurological problems, which suggests that intrauterine VZV infection can be acquired without cutaneous symptoms in the mother.
四名惊厥新生儿的脑脊液（CSF）中存在针对水痘带状疱疹病毒（VZV）的IgG抗体。其中两名患者在6个月龄后血清中也发现了这些抗体。对201名有神经问题的新生儿的血清和脑脊液中针对16种不同微生物的抗体进行了研究。还使用聚合酶链反应（PCR）检测了脑脊液中特异性针对单纯疱疹病毒1型（HSV-1）、单纯疱疹病毒2型（HSV-2）和水痘带状疱疹病毒（VZV）的DNA的存在情况。在四名新生儿的脑脊液中检测到了针对VZV的抗体。抗体指数表明中枢神经系统产生了VZV特异性抗体。这些发现表明，有神经问题的新生儿可能出现鞘内产生针对VZV的抗体，这表明母亲在子宫内感染VZV时可能没有皮肤症状。
