Jaeger H J, Kolb S, Mair T, Geller M, Christmann A, Kinne R K, Mathias K D
Department of Diagnostic Radiology, Städtische Kliniken Dortmund, Germany.
J Vasc Interv Radiol. 1998 Mar-Apr;9(2):295-304. doi: 10.1016/s1051-0443(98)70272-6.
To determine the experimental parameters in an in vitro model that influence the thrombus-capturing efficacy of the Vena Tech-LGM filter.
The Vena Tech-LGM filter was evaluated in an in vitro model of the vena cava with a computer-controlled flow system with a total of 5,200 thrombi. The influences of the following experimental parameters on the capture rate were analyzed with a multiple logistic regression model: type of testing (single, double, and multiple shot testing), thrombus diameter and length, IVC diameter and orientation, flow quality and quantity, flow velocity, and the length of the prepositioned thrombus.
A significant influence on the capture rate could be demonstrated for the type of testing, the thrombus diameter and length, the IVC diameter, and with double shot testing for the length of the prepositioned thrombus and the IVC orientation. The flow quality and the peak velocity were not significant. Based on these results, a protocol for in vitro testing of IVC filters was designed.
Experimental parameters influence the thrombus-capturing efficacy of the Vena Tech-LGM filter and should be taken into account when in vitro testing is performed.
确定体外模型中影响Vena Tech-LGM滤器血栓捕获效能的实验参数。
采用计算机控制的血流系统，在腔静脉体外模型中对Vena Tech-LGM滤器进行评估，共使用5200个血栓。使用多元逻辑回归模型分析以下实验参数对捕获率的影响：测试类型（单次、两次和多次注射测试）、血栓直径和长度、下腔静脉直径和方向、血流质量和数量、流速以及预先放置血栓的长度。
测试类型、血栓直径和长度、下腔静脉直径以及两次注射测试中预先放置血栓的长度和下腔静脉方向对捕获率有显著影响。血流质量和峰值流速无显著影响。基于这些结果，设计了一项下腔静脉滤器体外测试方案。
实验参数影响Vena Tech-LGM滤器的血栓捕获效能，在进行体外测试时应予以考虑。
