Jonas J B, Gründler A E
Universitäts-Augenklinik, Erlangen, Germany.
Graefes Arch Clin Exp Ophthalmol. 1998 Mar;236(3):202-6. doi: 10.1007/s004170050065.
This study was carried out to evaluate the prevalence of diabetes mellitus and arterial hypertension in the open-angle glaucomas.
The study consisted of 529 patients with primary open-angle glaucoma, including 170 patients with the age-related atrophic type and 22 patients with the highly myopic type; 152 patients with secondary open-angle glaucoma, including 85 patients with pseudoexfoliative glaucoma; 56 patients with the focal type of normal-pressure glaucoma; and 660 nonglaucomatous subjects in the control group. For all study groups, age-matched control groups were formed.
Prevalence of diabetes mellitus and arterial hypertension did not vary significantly (P > 0.25; chi-square test) between the non-highly myopic primary open-angle glaucoma groups and the control groups. In highly myopic primary open-angle glaucoma, pseudoexfoliative glaucoma, and focal normal-pressure glaucoma, diabetes mellitus and arterial hypertension were less common; however, not in all cases was the difference from the control group significant.
The results suggest that diabetes mellitus and arterial hypertension are not more common in patients with primary and secondary open-angle glaucomas than in age-matched nonglaucomatous subjects. In agreement with some previous epidemiologic studies, diabetes mellitus and arterial hypertension may not be positively associated with the primary or secondary open-angle glaucomas.
本研究旨在评估开角型青光眼患者中糖尿病和动脉高血压的患病率。
该研究纳入了529例原发性开角型青光眼患者，其中包括170例年龄相关性萎缩型患者和22例高度近视型患者；152例继发性开角型青光眼患者，其中包括85例假性剥脱性青光眼患者；56例局部型正常眼压性青光眼患者；以及对照组的660例非青光眼受试者。为所有研究组设立了年龄匹配的对照组。
非高度近视原发性开角型青光眼组与对照组之间糖尿病和动脉高血压的患病率无显著差异（P>0.25；卡方检验）。在高度近视原发性开角型青光眼、假性剥脱性青光眼和局部型正常眼压性青光眼中，糖尿病和动脉高血压的情况较少见；然而，并非在所有情况下与对照组的差异都具有显著性。
结果表明，原发性和继发性开角型青光眼患者中糖尿病和动脉高血压并不比年龄匹配的非青光眼受试者更常见。与先前的一些流行病学研究一致，糖尿病和动脉高血压可能与原发性或继发性开角型青光眼无正相关。
