Nelson S J, Vigneron D B, Star-Lack J, Kurhanewicz J
Department of Radiology, University of California San Francisco 94143, USA.
NMR Biomed. 1997 Dec;10(8):411-22. doi: 10.1002/(sici)1099-1492(199712)10:8<411::aid-nbm496>3.0.co;2-8.
The in vivo applications of magnetic resonance spectroscopic imaging (MRSI) have expanded significantly over the past 10 years and have reached the point where clinical trials are underway for a number of different diseases. One of the limiting factors in the widespread use of this technology has been the lack of widely available tools for obtaining data which are localized to sufficiently small tissue volumes to make an impact upon diagnosis and treatment planning. This is especially difficult within the timeframe of a clinical MR examination, which requires that both anatomic and metabolic data are acquired and processed. Recent advances in the hardware and software associated with clinical scanners have provided the potential for improvements in the spatial and time resolution of imaging and spectral data. The two areas which hold the most promise in terms of MRSI data are the use of phased array coils and the implementation of echo planar k-space sampling techniques. These could have immediate impact for 1H MRSI and may prove valuable for future applications of 31P MRSI.
在过去十年中，磁共振波谱成像（MRSI）的体内应用显著扩展，已达到针对多种不同疾病开展临床试验的阶段。该技术广泛应用的限制因素之一是缺乏广泛可用的工具来获取局限于足够小的组织体积的数据，以对诊断和治疗规划产生影响。在临床磁共振检查的时间范围内，这尤其困难，因为需要采集和处理解剖学和代谢数据。与临床扫描仪相关的硬件和软件的最新进展为提高成像和光谱数据的空间和时间分辨率提供了潜力。就MRSI数据而言，最有前景的两个领域是相控阵线圈的使用和回波平面k空间采样技术的应用。这些可能会对氢质子MRSI立即产生影响，并且可能对未来磷-31 MRSI的应用具有重要价值。
