Yokoyama Y, Takahashi Y, Morishita S, Hashimoto M, Niwa K, Tamaya T
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.
Mol Hum Reprod. 1998 Feb;4(2):173-7. doi: 10.1093/molehr/4.2.173.
In a total of 41 endometrial tissue samples, the relationship between telomerase activity and proliferating cell nuclear antigen (PCNA) labelling index was studied. In samples of endometrium from the proliferative phase of the menstrual cycle, telomerase activity was found in 15 out of 17 cases (88%). Two samples from the early proliferative phase showed negative telomerase activity and a low PCNA labelling index. However, three out of 16 samples of early secretory phase endometrium showed telomerase activity and a PCNA labelling index. In mid- to late secretory phase endometrium, in menopausal endometrium and in decidualized endometrium induced by progesterone neither telomerase activity nor PCNA labelling was found. These results suggest that telomerase activity of the endometrium may be correlated with the proliferative potential of the epithelial cells and that its activity may be regulated by oestrogen.
在总共41份子宫内膜组织样本中，研究了端粒酶活性与增殖细胞核抗原（PCNA）标记指数之间的关系。在月经周期增殖期的子宫内膜样本中，17例中有15例（88%）检测到端粒酶活性。来自增殖早期的两个样本显示端粒酶活性为阴性且PCNA标记指数较低。然而，16份分泌早期子宫内膜样本中有3份显示端粒酶活性和PCNA标记指数。在分泌中期至晚期子宫内膜、绝经后子宫内膜以及由孕酮诱导的蜕膜化子宫内膜中，均未发现端粒酶活性和PCNA标记。这些结果表明，子宫内膜的端粒酶活性可能与上皮细胞的增殖潜能相关，并且其活性可能受雌激素调节。
