Ficker J H, Dertinger S H, Siegfried W, König H J, Pentz M, Sailer D, Katalinic A, Hahn E G
Medical Department I, University of Erlangen-Nuremburg, Erlangen, Germany.
Eur Respir J. 1998 Jan;11(1):14-9. doi: 10.1183/09031936.98.11010014.
Knowledge of conditions associated with an increased prevalence of obstructive sleep apnoea (OSA) may help to identify patients with OSA and might give some insight into the pathogenesis of OSA and its sequelae. A number of earlier, smaller studies hinted at an association between diabetic cardiovascular autonomic neuropathy (AN) and OSA. The present study was, therefore, conducted with the aim of establishing the prevalence of OSA in diabetics with AN and of determining whether OSA is more prevalent in diabetics with AN, than in those without. We studied two groups of diabetic patients: 23 with and 25 without AN. All patients were evaluated for possible OSA (apnoea/hypopnoea index > or = 10) using initial ambulatory screening followed by polysomnography. Six patients with AN (26%) were found to have OSA, but none of the patients without AN met the diagnostic criteria (p<0.01). When the patients with OSA were compared to those without, no differences were found in terms of age, sex, body mass index or diabetes type or duration. In conclusion, about one in four diabetic patients with autonomic neuropathy suffers from OSA. Thus, obstructive sleep apnoea is more prevalent in diabetic patients with autonomic neuropathy, than in those without.
了解与阻塞性睡眠呼吸暂停（OSA）患病率增加相关的情况，可能有助于识别OSA患者，并可能为OSA及其后遗症的发病机制提供一些见解。一些早期的小型研究暗示糖尿病心血管自主神经病变（AN）与OSA之间存在关联。因此，本研究旨在确定患有AN的糖尿病患者中OSA的患病率，并确定患有AN的糖尿病患者中OSA是否比未患AN的患者更普遍。我们研究了两组糖尿病患者：23例患有AN的患者和25例未患AN的患者。所有患者均通过初始动态筛查，随后进行多导睡眠图检查，以评估是否可能患有OSA（呼吸暂停/低通气指数≥10）。发现6例患有AN的患者（26%）患有OSA，但没有AN的患者均未达到诊断标准（p<0.01）。将患有OSA的患者与未患OSA的患者进行比较时，在年龄、性别、体重指数、糖尿病类型或病程方面未发现差异。总之，约四分之一患有自主神经病变的糖尿病患者患有OSA。因此，阻塞性睡眠呼吸暂停在患有自主神经病变的糖尿病患者中比在未患自主神经病变的患者中更普遍。
