Miwa H, Koshimura I, Mizuno Y
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
J Neurol Sci. 1998 Jan 21;154(1):101-5. doi: 10.1016/s0022-510x(97)00205-0.
We report 14 patients with idiopathic recurrent cranial neuropathy, in whom multiple cranial nerves were involved recurrently, either at the same or different times, and appeared bilaterally. Oculomotor nerve involvement was most frequent, while the abducens and facial nerves were the next most frequent. Clinical courses were benign and not progressive, and the symptoms responded well to corticosteroids. Ten patients developed Tolosa-Hunt syndrome during the course of their illness. Laboratory findings and CSF were normal. MRI and CT studies were unremarkable, except for an asymmetric appearance of the cavernous sinus in some patients. One patient showed focal hypertrophic pachymeningitis in the posterior fossa in MRI. We discuss the relationship of the idiopathic recurrent cranial neuropathy with disorders characterized by inflammation of the dura mater, such as Tolosa-Hunt syndrome and cranial pachymeningitis.
我们报告了14例特发性复发性颅神经病变患者，这些患者的多条颅神经在相同或不同时间反复受累，且呈双侧出现。动眼神经受累最为常见，其次是外展神经和面神经。临床病程呈良性且无进展，症状对皮质类固醇反应良好。10例患者在病程中出现了托洛萨-亨特综合征。实验室检查结果和脑脊液均正常。除部分患者海绵窦外观不对称外，MRI和CT检查无明显异常。1例患者MRI显示后颅窝局灶性肥厚性硬脑膜炎。我们讨论了特发性复发性颅神经病变与以硬脑膜炎症为特征的疾病（如托洛萨-亨特综合征和颅硬脑膜炎）之间的关系。
