Fraser H S, Bulpitt C J, Kahn C, Mould G, Mucklow J C, Dollery C T
Clin Pharmacol Ther. 1976 Sep;20(3):369-76. doi: 10.1002/cpt1976203369.
Saliva half-life of antipyrine was studied in 49 healthy Gambians between 20 and 60 yr of age of whom 27 were male (mean age, 44.5) and 22 female (mean age, 39.1). Body wieght, height, ponderal index, albumin, and hemoglobin were moderately reduced compared to accepted normal values. Antipyrine half-life was 13.6 +/- 0.58 (SEM) hr. Multiple regression analysis showed that sex, cola nut consumption, hemoglobin in women, and height in men were statiscally significant independent predictors of antipyrine half-life. Half-life was shorter in women, decreased with an increase in height in men, and was prolonged by cola nut consumption. Half-life in women increased with hemoglobin. These factors explained 36% of the variation and suggest that geographic differences in the environment could be important in drug metabolism in man.
对49名年龄在20至60岁之间的健康冈比亚人进行了安替比林唾液半衰期的研究，其中27名男性（平均年龄44.5岁），22名女性（平均年龄39.1岁）。与公认的正常值相比，体重、身高、体重指数、白蛋白和血红蛋白均有中度降低。安替比林半衰期为13.6±0.58（标准误）小时。多元回归分析表明，性别、可乐果摄入量、女性血红蛋白水平和男性身高是安替比林半衰期具有统计学意义的独立预测因素。女性的半衰期较短，男性半衰期随身高增加而降低，可乐果摄入会延长半衰期。女性的半衰期随血红蛋白水平升高而增加。这些因素解释了36%的变异，表明环境中的地理差异可能对人体药物代谢具有重要影响。
