Hughes K, Choo M, Kuperan P, Ong C N, Aw T C
Department of Community, Occupational and Family Medicine, National University of Singapore, National University Hospital, Singapore.
Atherosclerosis. 1998 Jan;136(1):25-31. doi: 10.1016/s0021-9150(97)00180-9.
Cardiovascular risk factors were compared between 126 people with non-insulin-dependent diabetes mellitus (NIDDM) and 530 non-diabetics (controls), in a random sample of people (Chinese, Malays, and Asian Indians) aged 40-69 years from the general population of Singapore. Data were adjusted for age and ethnicity. For both genders, people with NIDDM had higher mean body mass indices, waist-hip ratios and abdominal diameters. They also had a higher prevalence of hypertension, higher mean levels of fasting serum triglyceride, slightly lower mean levels of serum high-density-lipoprotein cholesterol, and higher mean levels of plasma plasminogen activator inhibitor-1 and tissue plasminogen activator (antigen). These factors are components of syndrome X (metabolic syndrome) and increase the risk of atherosclerosis and thrombosis. In contrast, there were no important differences for cigarette smoking, serum total and low-density-lipoprotein cholesterol, serum apolipoproteins A1 and B, plasma factor VIIc and plasma prothrombin fragment 1 + 2. Females with NIDDM, but not males, had a higher mean serum fibrinogen level than non-diabetics, which could explain why NIDDM has a greater cardiovascular effect in females than males. Serum lipoprotein(a) concentrations were lower in people with NIDDM. Mean levels of serum ferritin, a pro-oxidant, were higher in people with NIDDM than controls, but there were no important differences for plasma vitamins A, C and E, and serum selenium, which are anti-oxidants.
在一项从新加坡普通人群中随机抽取的40至69岁人群（包括华人、马来人和亚洲印度人）的样本中，对126名非胰岛素依赖型糖尿病（NIDDM）患者和530名非糖尿病患者（对照组）的心血管危险因素进行了比较。数据根据年龄和种族进行了调整。对于男女两性而言，NIDDM患者的平均体重指数、腰臀比和腹径更高。他们患高血压的患病率也更高，空腹血清甘油三酯的平均水平更高，血清高密度脂蛋白胆固醇的平均水平略低，血浆纤溶酶原激活物抑制剂-1和组织纤溶酶原激活物（抗原）的平均水平更高。这些因素是X综合征（代谢综合征）的组成部分，会增加动脉粥样硬化和血栓形成的风险。相比之下，在吸烟、血清总胆固醇和低密度脂蛋白胆固醇、血清载脂蛋白A1和B、血浆因子VIIc以及血浆凝血酶原片段1 + 2方面没有重要差异。患有NIDDM的女性而非男性的平均血清纤维蛋白原水平高于非糖尿病患者，这可以解释为什么NIDDM对女性的心血管影响大于男性。NIDDM患者的血清脂蛋白(a)浓度较低。作为促氧化剂的血清铁蛋白的平均水平在NIDDM患者中高于对照组，但作为抗氧化剂的血浆维生素A、C和E以及血清硒方面没有重要差异。
