Tajaddini Mohammad Hasan, Keikha Mojtaba, Razzazzadeh Ali, Kelishadi Roya
Department of Physiology, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2015 Aug;20(8):782-9. doi: 10.4103/1735-1995.168403.
This systematic review paper aims to study the experimental and human studies on the relationship between metabolic syndrome (MetS), its component and selenium (Se) concentration.
The literature was searched in PubMed, Scopus, and Google Scholar databases with no time limitation using MetS X and Se key words in medical subject heading. The related papers were selected in three phases. After quality assessment, two reviewers extracted the data, whereas the third reviewer checked their extracted data. All evidence comes from experimental and laboratory studies.
Finally, 18 articles were included. While, some studies documented that as an antioxidant agent, Se might be correlated with endothelial function, large controversy exists about the type of correlation including positive, negative, and no correlation between MetS and Se levels in body. Some of the reviewed studies were focused on antioxidant supplementation effects on MetS, results also varied in this regard.
This inconsistency could be because of diversity in study design, population, lack of special focus on Se and MetS, and finally the complex nature of MetS.
本系统评价论文旨在研究关于代谢综合征（MetS）及其组分与硒（Se）浓度之间关系的实验研究和人体研究。
在PubMed、Scopus和谷歌学术数据库中进行文献检索，使用医学主题词中的MetS X和Se关键词，无时间限制。相关论文分三个阶段进行筛选。在质量评估后，两名评审员提取数据，第三名评审员检查他们提取的数据。所有证据均来自实验研究和实验室研究。
最终纳入18篇文章。虽然一些研究记录了作为抗氧化剂的硒可能与内皮功能相关，但关于MetS与体内硒水平之间的相关性类型存在很大争议，包括正相关、负相关和无相关性。一些综述研究关注抗氧化剂补充对MetS的影响，在这方面结果也各不相同。
这种不一致可能是由于研究设计、人群的多样性，缺乏对硒和MetS的特别关注，以及最终MetS的复杂性质。
