一种由链霉菌产生的新型拓扑异构酶II抑制剂BE-22179。I. 产生菌株、发酵、分离及生物活性。
A new topoisomerase II inhibitor, BE-22179, produced by a streptomycete. I. Producing strain, fermentation, isolation and biological activity.
作者信息
Okada H, Suzuki H, Yoshinari T, Arakawa H, Okura A, Suda H, Yamada A, Uemura D
机构信息
New Drug Discovery Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Japan.
出版信息
J Antibiot (Tokyo). 1994 Feb;47(2):129-35. doi: 10.7164/antibiotics.47.129.
A new topoisomerase II inhibitor, designated BE-22179, was isolated from the culture broth of Streptomyces sp. A22179, which resembles "Streptomyces gangtokensis". The inhibitor was extracted from the mycelial cake of the culture broth with organic solvent and successively purified by silica gel chromatography. BE-22179 inhibited topoisomerase II strongly but not topoisomerase I and showed potent antitumor activity against various tumor cell lines both in vitro and in vivo.
一种新的拓扑异构酶II抑制剂，命名为BE - 22179，是从类似于“甘托克链霉菌”的链霉菌属菌株A22179的培养液中分离得到的。该抑制剂用有机溶剂从培养液的菌丝饼中提取，然后通过硅胶柱色谱法依次纯化。BE - 22179强烈抑制拓扑异构酶II，但不抑制拓扑异构酶I，并且在体外和体内对多种肿瘤细胞系均显示出强大的抗肿瘤活性。
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