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来自假诺卡氏菌属的具有选择性强效抗幽门螺杆菌活性的新型喹诺酮化合物：产生菌的分类学、发酵、分离、结构解析及生物学活性

New quinolone compounds from Pseudonocardia sp. with selective and potent anti-Helicobacter pylori activity: taxonomy of producing strain, fermentation, isolation, structural elucidation and biological activities.

作者信息

Dekker K A, Inagaki T, Gootz T D, Huang L H, Kojima Y, Kohlbrenner W E, Matsunaga Y, McGuirk P R, Nomura E, Sakakibara T, Sakemi S, Suzuki Y, Yamauchi Y, Kojima N

机构信息

Central Research Division, Pfizer Pharmaceuticals Inc., Aichi, Japan.

出版信息

J Antibiot (Tokyo). 1998 Feb;51(2):145-52. doi: 10.7164/antibiotics.51.145.

DOI:10.7164/antibiotics.51.145
PMID:9544935
Abstract

Eight novel quinolones with anti-Helicobacter pylori activity were isolated from the actinomycete Pseudonocardia sp. CL38489. The quinolones were very potent against H. pylori with MICs up to 0.1 ng/ml. The quinolones appear to be specific for H. pylori, since they did not show antimicrobial activity when tested against a panel of other microorganisms.

摘要

从放线菌假诺卡氏菌属CL38489中分离出8种具有抗幽门螺杆菌活性的新型喹诺酮。这些喹诺酮对幽门螺杆菌具有很强的活性，最低抑菌浓度高达0.1纳克/毫升。这些喹诺酮似乎对幽门螺杆菌具有特异性，因为在针对一组其他微生物进行测试时，它们没有显示出抗菌活性。

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