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由sp.属的一种根际细菌产生的两种新型2-烷基喹诺酮，对鱼皮肤溃疡病原体具有抑制作用。

Two new 2-alkylquinolones, inhibitory to the fish skin ulcer pathogen , produced by a rhizobacterium of the genus sp.

作者信息

Li Dandan, Oku Naoya, Hasada Atsumi, Shimizu Masafumi, Igarashi Yasuhiro

机构信息

Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

Laboratory of Plant Pathology, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

出版信息

Beilstein J Org Chem. 2018 Jun 14;14:1446-1451. doi: 10.3762/bjoc.14.122. eCollection 2018.

DOI:10.3762/bjoc.14.122
PMID:29977408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6009182/
Abstract

Exploration of rhizobacteria of the genus as an under-tapped resource of bioactive molecules resulted in the isolation of two new antimicrobial 2-alkyl-4-quinolones. ()-2-(Hept-2-en-1-yl)quinolin-4(1)-one () and ()-2-(non-2-en-1-yl)quinolin-4(1)-one () were isolated from the culture broth of strain MBAF1239 together with four known alkylquinolones ( and -), pyrrolnitrin (), and BN-227 (). The structures of and were unambiguously characterized using NMR spectroscopy and mass spectrometry. Compounds - inhibited the growth of the marine bacterium , an etiological agent of skin ulcers in marine fish, offering new opportunities to develop antibacterial drugs for fish farming.

摘要

对作为生物活性分子未开发资源的根际细菌属进行探索，导致分离出两种新的抗菌2-烷基-4-喹诺酮。（）-2-（庚-2-烯-1-基）喹啉-4（1）-酮（）和（）-2-（壬-2-烯-1-基）喹啉-4（1）-酮（）与四种已知的烷基喹诺酮（和-）、吡咯菌素（）和BN-227一起从菌株MBAF1239的培养液中分离出来。和的结构通过核磁共振光谱和质谱进行了明确表征。化合物-抑制了海洋细菌的生长，该细菌是海水鱼类皮肤溃疡的病原体，为开发用于养鱼业的抗菌药物提供了新机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b252/6009182/0e78268f34f1/Beilstein_J_Org_Chem-14-1446-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b252/6009182/98d075e302e8/Beilstein_J_Org_Chem-14-1446-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b252/6009182/94f520da7c68/Beilstein_J_Org_Chem-14-1446-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b252/6009182/0e78268f34f1/Beilstein_J_Org_Chem-14-1446-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b252/6009182/98d075e302e8/Beilstein_J_Org_Chem-14-1446-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b252/6009182/94f520da7c68/Beilstein_J_Org_Chem-14-1446-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b252/6009182/0e78268f34f1/Beilstein_J_Org_Chem-14-1446-g004.jpg

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