根赤壳菌素、庚特酸及其他真菌代谢产物的抗疟活性
Antimalarial activity of radicicol, heptelidic acid and other fungal metabolites.
作者信息
Tanaka Y, Shiomi K, Kamei K, Sugoh-Hagino M, Enomoto Y, Fang F, Yamaguchi Y, Masuma R, Zhang C G, Zhang X W, Omura S
机构信息
Research Center for Biological Function, The Kitasato Institute, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1998 Feb;51(2):153-60. doi: 10.7164/antibiotics.51.153.
In the course of our screening program for artemisinin-like antimalarial compounds from microorganisms, seven fungal metabolites such as radicicol and heptelidic acid were identified as active compounds. Some of them exhibited antimalarial activity in vitro against the human malaria parasite Plasmodium falciparum to the extent of approximately 1/10 as potent as artemisinin. Radicicol was moderately active in vivo against Plasmodium berghei in mice.
在我们从微生物中筛选青蒿素类抗疟化合物的过程中，鉴定出了七种真菌代谢产物，如萝卜宁和庚二烯酸，它们为活性化合物。其中一些在体外对人类疟原虫恶性疟原虫表现出抗疟活性，其效力约为青蒿素的1/10。萝卜宁在体内对小鼠伯氏疟原虫有中等活性。
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