从熊状小香菇培养物中分离出的三种新的庚二酸衍生物。

Liu Li, Han Jun-Jie, Xu Tian-Shun, Liu Rui-Xing, Bao Li, Liu Hong-Wei

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.

Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.

Nat Prod Bioprospect. 2018 Oct;8(5):355-360. doi: 10.1007/s13659-018-0168-8. Epub 2018 May 22.

Three new heptelidic acid derivatives (1-3) including two new dimeric esters and two known heptelidic acid analogues (4 and 5) were isolated from the solid culture of mushroom Lentinellus ursinus. The structures of new compounds were confirmed by the analysis of NMR and HRESIMS spectroscopic data. The biosynthetic origin of compounds 1-5 was postulated. Compounds 1-5 exhibited no antibacterial activity against Staphylococcus aureus and Escherichia coli at the dose of 100 μM.

从香菇的固体培养物中分离出三种新的庚特尔酸衍生物（1-3），包括两种新的二聚体酯和两种已知的庚特尔酸类似物（4和5）。通过核磁共振（NMR）和高分辨电喷雾电离质谱（HRESIMS）光谱数据分析确定了新化合物的结构。推测了化合物1-5的生物合成起源。化合物1-5在100μM剂量下对金黄色葡萄球菌和大肠杆菌没有抗菌活性。