Peachey P R, Gubbins P O, Martin R E
Arkansas Poison Control/Drug Information Center, Little Rock, USA.
Pharmacotherapy. 1998 Mar-Apr;18(2):255-64.
The varieties of Cryptococcus neoformans serotypes are neoformans and gattii. Data suggest an association between cryptococcal variety and host immune status. In addition, the two varieties differ in their epidemiology and pathogenicity. Furthermore, symptoms, outcome, and response of cryptococcosis to antifungal therapy may vary. The two varieties also differ in immune-modulating effects. Sparse clinical data suggest var. gattii is more virulent and may be more recalcitrant to antifungal therapy. Also, its infections produce more sequelae. A better understanding of how cryptococcal variety influences the clinical course and response to the treatment of cryptococcosis is needed. Clinicians should be aware of the association, especially in patients with refractory disease. It may be useful to type the isolate to the variety level and administer prolonged antifungal therapy.
新型隐球菌血清型的种类为新生型和格特隐球菌型。数据表明隐球菌种类与宿主免疫状态之间存在关联。此外，这两个种类在流行病学和致病性方面存在差异。而且，隐球菌病对抗真菌治疗的症状、转归及反应可能有所不同。这两个种类在免疫调节作用方面也存在差异。稀少的临床数据表明，格特隐球菌型的毒性更强，可能对抗真菌治疗更具耐药性。此外，其感染会产生更多后遗症。需要更好地了解隐球菌种类如何影响隐球菌病的临床病程及对治疗的反应。临床医生应意识到这种关联，尤其是在患有难治性疾病的患者中。将分离株鉴定到种类水平并进行延长疗程的抗真菌治疗可能是有用的。
