Asai K, Fujita K, Yamamoto M, Hotta T, Morikawa M, Kokubo M, Moriyama A, Kato T
Department of Bioregulation Research, Nagoya City University Medical School, Japan.
Biochim Biophys Acta. 1998 Mar 13;1396(3):242-4. doi: 10.1016/s0167-4781(97)00222-4.
A novel full-length human cDNA homologous to Glia Maturation Factor-beta (GMF-beta) gene was isolated. Sequence analysis of the entire cDNA revealed an open reading frame of 426 nucleotides with a deduced protein sequence of 142 amino acid residues. The deduced amino acid sequences of its putative product is highly homologous to human GMF-beta (82% identity) and named for GMF-gamma. Northern blot analysis indicated that a message of 0.9 kb long, but not 4.1 kb of GMF-beta, is predominantly expressed in human lung, heart, and placenta.
分离出了一个与胶质细胞成熟因子-β（GMF-β）基因同源的新型全长人类cDNA。对整个cDNA的序列分析显示有一个426个核苷酸的开放阅读框，其推导的蛋白质序列有142个氨基酸残基。其推定产物的推导氨基酸序列与人类GMF-β高度同源（同一性为82%），并命名为GMF-γ。Northern印迹分析表明，一条0.9kb长的信息，而非GMF-β的4.1kb信息，在人类肺、心脏和胎盘中主要表达。
