Solomon G S, Petrie W M, Hart J R, Brackin H B
J Neuropsychiatry Clin Neurosci. 1998 Winter;10(1):64-7. doi: 10.1176/jnp.10.1.64.
This study tested the hypothesis that olfactory dysfunction could discriminate between groups of patients with Alzheimer's disease and major depression. Forty patients meeting DSM-IV criteria for Alzheimer's disease and for major depression (20 per group) underwent assessment with the Pocket Smell Test (PST), a three-item screening measure of cranial nerve I function. A PST score of < or = 1 (1 or 0 correct) discriminated between the groups with a hit rate of 90% (sensitivity = 80%, specificity = 100%). Olfactory assessment may be a useful adjunctive screening measure in differentiating Alzheimer's disease from depression in elderly patients.
本研究检验了嗅觉功能障碍可区分阿尔茨海默病患者和重度抑郁症患者这一假设。40名符合《精神疾病诊断与统计手册》第四版（DSM-IV）中阿尔茨海默病和重度抑郁症标准的患者（每组20名）接受了简易嗅觉测试（PST）评估，这是一项用于评估嗅神经I功能的三项筛查指标。PST得分≤1（答对1题或0题）可区分这两组患者，命中率为90%（敏感性 = 80%，特异性 = 100%）。嗅觉评估可能是老年患者区分阿尔茨海默病和抑郁症的一项有用的辅助筛查手段。
