Spiessens C, D'Hooghe T, Wouters E, Meuleman C, Vanderschueren D
Leuven University Fertility Centre, University Hospital Leuven, Belgium.
Fertil Steril. 1998 Apr;69(4):735-9. doi: 10.1016/s0015-0282(97)00569-4.
To test the hypothesis that alpha-glycosidase activity in seminal plasma can predict the outcome of both IUI and IVF.
A retrospective cohort study.
Tertiary fertility center in a university hospital.
PATIENT(S): Eighty-three subfertile couples who underwent IUI and 125 subfertile couples who underwent IVF.
None.
MAIN OUTCOME MEASURE(S): Determination of the alpha-glycosidase activity in seminal plasma before an IUI or IVF attempt, correlation of alpha-glycosidase activity and other semen parameters, and prediction of pregnancy using alpha-glycosidase activity in seminal plasma.
RESULT(S): Alpha-glycosidase activity correlated with sperm count. In the IUI group, alpha-glycosidase activity of >23.9 mU/mL predicted pregnancy with a sensitivity of 100% and a specificity of 55.2%. In the IVF group, the outcome could not be predicted with use of any of the semen parameters.
CONCLUSION(S): Alpha-glycosidase activity measured in mU/mL probably can be used as a predictor for IVF and pregnancy in an IUI program but has no predictive value with regard to pregnancy rate in an IVF program.
检验精浆中α-糖苷酶活性可预测宫腔内人工授精（IUI）和体外受精（IVF）结果的假设。
一项回顾性队列研究。
一所大学医院的三级生殖中心。
83对接受IUI的不育夫妇和125对接受IVF的不育夫妇。
无。
在进行IUI或IVF尝试前测定精浆中α-糖苷酶活性，α-糖苷酶活性与其他精液参数的相关性，以及使用精浆中α-糖苷酶活性预测妊娠情况。
α-糖苷酶活性与精子计数相关。在IUI组中，α-糖苷酶活性>23.9 mU/mL预测妊娠的敏感性为100%，特异性为55.2%。在IVF组中，使用任何精液参数均无法预测结果。
以mU/mL为单位测量的α-糖苷酶活性可能可作为IUI方案中IVF和妊娠的预测指标，但对于IVF方案中的妊娠率没有预测价值。
