Anderson Ashleigh, McConville Aaron, Fanthorpe Laura, Davis James
School of Engineering, Ulster University, Jordanstown, Northern Ireland BT37 0QB, UK.
Medicines (Basel). 2017 Jun 30;4(3):48. doi: 10.3390/medicines4030048.
The pain relief capabilities of methyl salicylate are well established and a multitude of over-the-counter products populate pharmacy shelves. Over-application of the topical preparation containing the drug, or its accidental ingestion, invariably result in salicylate poisoning and in severe cases can be fatal. The drug has been a regular feature of the US National Poison Database Survey over the past decade and continues to pose a risk to children and adults alike. The aim of the review has been to cast a spotlight on the drug and assess why its use remains problematic, how technology could offer more efficacious delivery regimes, and minimise the possibility of accidental or intentional misuse.
水杨酸甲酯的止痛功效已得到充分证实，众多非处方产品摆满了药店的货架。含有该药物的外用制剂使用过量或意外摄入，都会导致水杨酸盐中毒，严重时可能会致命。在过去十年中，该药物一直是美国国家毒物数据库调查的常见对象，对儿童和成人都依然构成风险。本次综述的目的是关注该药物，评估其使用为何仍然存在问题、技术如何能提供更有效的给药方式，以及将意外或故意滥用的可能性降至最低。
