Katsuno K, Manabe A, Hasegawa T, Nakayama S, Itoh K, Wakumoto S, Hisamitsu H
Showa University School of Dentistry.
Dent Mater J. 1992 Jun;11(1):77-82. doi: 10.4012/dmj.11.77.
We studied the allergic reaction of guinea pigs to glyceryl methacrylate (GM), hydroxyethyl methacrylate (HEMA) and meso-erythritol methacrylate (EM), which are used as dentin primers. On the 18th day of the application test, when macroscopic investigation revealed an inflammatory reaction, the methacrylic acid-treated group showed marked eschar formation in comparison with the control group. In each of the dentin primer groups, a slight degree of skin redness was noted, but there were no serious symptoms. On the 25th day, the applications were resumed macroscopic inspection on the 32nd day found eschar in the methacrylic acid group only. Therefore, this experiment with dentin primers suggests a delayed allergic reaction. Local irritability test showed a more severe reaction than the application test. In this test, all experimental dentin primers and methacrylic solution promptly showed inflammation, and the chemical compound, methacrylic acid was a factor in inflammation.
我们研究了豚鼠对用作牙本质底漆的甲基丙烯酸甘油酯（GM）、甲基丙烯酸羟乙酯（HEMA）和甲基丙烯酸内消旋赤藓糖醇酯（EM）的过敏反应。在应用测试的第18天，当宏观检查显示有炎症反应时，与对照组相比，甲基丙烯酸处理组出现了明显的焦痂形成。在每个牙本质底漆组中，均观察到轻微程度的皮肤发红，但无严重症状。在第25天恢复应用，在第32天的宏观检查中仅在甲基丙烯酸组发现了焦痂。因此，这项关于牙本质底漆的实验表明存在迟发性过敏反应。局部刺激性测试显示出比应用测试更严重的反应。在该测试中，所有实验性牙本质底漆和甲基丙烯酸溶液均迅速出现炎症，并且化合物甲基丙烯酸是炎症的一个因素。
