Cuesta K H, Palazzo J P, Mittal K R
Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107, USA.
J Cutan Pathol. 1998 Mar;25(3):165-70. doi: 10.1111/j.1600-0560.1998.tb01710.x.
Anogenital squamous cell carcinoma has been noted with increased frequency in HIV-seropositive patients. Verrucous carcinoma is a variant of squamous cell carcinoma that tends to be locally invasive and non-metastasizing. Although human papillomavirus (HPV) has been strongly implicated in other squamous neoplasms, it has been variably associated with verrucous carcinoma and has not been examined in these lesions in the HIV-positive population. The aim of this study was to examine the association of HPV with anal verrucous carcinoma in patients with the human immunodeficiency virus (HIV). HPV DNA in situ hybridization for HPV Types 6/11, 16/18, and 31/33/35 was performed on formalin-fixed, paraffin-embedded tissue from six cases of verrucous carcinoma and four cases of condyloma acuminatum in perianal specimens from HIV-seropositive patients. HPV DNA sequences were identified in five of six cases of verrucous carcinoma and in all cases of condyloma acuminatum. Of the five verrucous carcinomas that harbored detectable HPV DNA, four contained HPV 6/11 and two contained HPV 16/18. One contained both HPV 6/11 and HPV 16/18. All four cases of condyloma acuminatum were positive for HPV 6/11. One patient included in this series had three chronologically separate verrucous carcinomas. The initial lesion was negative for HPV DNA. Subsequent verrucous carcinomas were positive for HPV type 6/11 and type 16/18, respectively. The data presented support the concept that verrucous carcinoma in the HIV-seropositive population is associated with HPV, which may indeed play an important role in its pathogenesis.
肛门生殖器鳞状细胞癌在HIV血清反应阳性患者中的发病率呈上升趋势。疣状癌是鳞状细胞癌的一种变体，往往具有局部侵袭性且不发生转移。虽然人乳头瘤病毒（HPV）与其他鳞状上皮肿瘤密切相关，但它与疣状癌的关系尚不明确，且尚未在HIV阳性人群的这些病变中进行研究。本研究的目的是探讨HPV与人类免疫缺陷病毒（HIV）患者肛门疣状癌之间的关联。对6例疣状癌和4例来自HIV血清反应阳性患者肛周标本的尖锐湿疣的福尔马林固定石蜡包埋组织进行HPV 6/11、16/18和31/33/35型的HPV DNA原位杂交。6例疣状癌中有5例和所有尖锐湿疣病例中均鉴定出HPV DNA序列。在检测到HPV DNA的5例疣状癌中，4例含有HPV 6/11，2例含有HPV 16/18。1例同时含有HPV 6/11和HPV 16/18。所有4例尖锐湿疣均为HPV 6/11阳性。该系列中的1例患者先后出现3个疣状癌。最初的病变HPV DNA检测为阴性。随后的疣状癌分别为HPV 6/11型和16/18型阳性。所提供的数据支持这样一种观点，即HIV血清反应阳性人群中的疣状癌与HPV有关，HPV可能在其发病机制中确实起着重要作用。
