Miyata M, Takase Y, Kobayashi H, Kokubun M, Yoshimura A, Katsuura Y, Nishimaki T, Kasukawa R
Department of Internal Medicine II, Fukushima Medical College, Hikarigaoka.
Intern Med. 1998 Feb;37(2):174-8. doi: 10.2169/internalmedicine.37.174.
Sjögren's syndrome and sarcoidosis share several common features, such as keratoconjunctivitis sicca, swelling of parotid glands, lung involvement, cutaneous anergy, T cell-mediated immunodeficiency, an increased CD4+/CD8+ lymphocyte ratio, and association with the human leucocyte antigen (HLA)-B 8 and DR 3 haplotypes. However, only five patients with primary Sjögren's syndrome and sarcoidosis have been previously reported in the English language literature. The rare case of a 49-year-old Japanese woman with primary Sjögren's syndrome complicated by sarcoidosis is described. The serum angiotensin-converting enzyme level was increased, and histological examination of lung and skin biopsies revealed noncaseating granulomas, indicating that her primary Sjögren's syndrome was complicated by sarcoidosis.
干燥综合征和结节病有几个共同特征，如干燥性角结膜炎、腮腺肿大、肺部受累、皮肤无反应性、T细胞介导的免疫缺陷、CD4+/CD8+淋巴细胞比值升高以及与人类白细胞抗原（HLA）-B8和DR3单倍型相关。然而，英文文献中此前仅报道过5例原发性干燥综合征合并结节病的患者。本文描述了1例罕见的49岁日本女性原发性干燥综合征合并结节病的病例。其血清血管紧张素转换酶水平升高，肺和皮肤活检的组织学检查显示为非干酪样肉芽肿，表明她的原发性干燥综合征合并了结节病。
