Machin N D, Chard M D, Paice E W
Postgrad Med J. 1984 Apr;60(702):270-1. doi: 10.1136/pgmj.60.702.270.
We report the case of an elderly woman with primary Sjogren's syndrome and abnormal liver function tests indicative of primary biliary cirrhosis. She was found to have a raised serum angiotensin converting enzyme activity. We proceeded to study 21 further cases of Sjogren's syndrome to discover whether raised levels of this enzyme were a feature of Sjogren's syndrome. None of them had any features to suggested associated primary biliary cirrhosis. The cases included 12 with associated rheumatoid arthritis, two with systemic sclerosis, three with systemic lupus erythematosus and four with primary Sjogren's syndrome. In only two of these 21 patients was a raised serum angiotensin converting enzyme obtained, the elevation being modest. We conclude that a raised activity of the enzyme is not usually associated with primary or secondary Sjogren's syndrome, and that discovery of such an abnormality should prompt a search for an associated condition.
我们报告了一例患有原发性干燥综合征且肝功能检查异常提示原发性胆汁性肝硬化的老年女性病例。发现她的血清血管紧张素转换酶活性升高。我们进而研究了另外21例干燥综合征病例，以确定该酶水平升高是否为干燥综合征的一个特征。这些病例中无一具有提示相关原发性胆汁性肝硬化的特征。病例包括12例合并类风湿关节炎、2例合并系统性硬化症、3例合并系统性红斑狼疮以及4例原发性干燥综合征。在这21例患者中，仅2例血清血管紧张素转换酶升高，且升高幅度不大。我们得出结论，该酶活性升高通常与原发性或继发性干燥综合征无关，发现这种异常应促使寻找相关疾病。
