Hewitt J K
Institute for Behavioral Genetics, University of Colorado, Boulder 80303, USA.
Psychopharmacol Bull. 1997;33(3):355-8.
Behavior genetics is concerned with the genetic and environmental influences on individual differences in the vulnerability to eating disorders. We should be skeptical about simple genetic explanations for disorders whose development, maintenance, and possible remission involve the interaction of individual behaviors and environmental circumstances. Twin, family, and adoption studies can help to delineate which phenotypes are most heritable, and which are most responsive to family circumstances or individual environments. Subsequent searches for individual genetic and environmental risk factors can be guided by these results. Although there is consistent evidence of genetic factors influencing vulnerability to eating disorders, the details are far from clear, and additional studies will be useful. The further development of dimensional indices of vulnerability will improve population-based and developmental genetic research, as well as facilitating the search for individual genes.
行为遗传学关注遗传和环境因素对饮食失调易感性个体差异的影响。对于那些其发展、维持和可能的缓解涉及个体行为与环境情况相互作用的疾病,我们应该对简单的遗传解释持怀疑态度。双胞胎、家庭和收养研究有助于确定哪些表型最具遗传性,哪些对家庭环境或个体环境最敏感。随后对个体遗传和环境风险因素的研究可以以这些结果为指导。虽然有一致的证据表明遗传因素影响饮食失调的易感性,但具体细节远未明确,进一步的研究将很有帮助。易感性维度指标的进一步发展将改善基于人群的发育遗传学研究,也有助于寻找个体基因。